(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-isopropylpyrimidin-5-yl]-3,5-dihydroxy-N-hydroxy-6-heptenamide

Base Information

Chemical Name:(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-isopropylpyrimidin-5-yl]-3,5-dihydroxy-N-hydroxy-6-heptenamide
CAS No.:1431473-61-8
Molecular Formula:C₂₂H₂₉FN₄O₆S
Molecular Weight:496.56
Hs Code.:

Synonyms:(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-isopropylpyrimidin-5-yl]-3,5-dihydroxy-N-hydroxy-6-heptenamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-isopropylpyrimidin-5-yl]-3,5-dihydroxy-N-hydroxy-6-heptenamide

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Technology Process of (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-isopropylpyrimidin-5-yl]-3,5-dihydroxy-N-hydroxy-6-heptenamide

There total 3 articles about (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-isopropylpyrimidin-5-yl]-3,5-dihydroxy-N-hydroxy-6-heptenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 287714-41-4
rosuvastatin

: 1431473-61-8
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-isopropylpyrimidin-5-yl]-3,5-dihydroxy-N-hydroxy-6-heptenamide

Guidance literature:: With hydroxylamine; In tetrahydrofuran; water; at 20 ℃; for 1h;
DOI:10.1021/jm400179b

Reference yield: 51.0%

: 503610-43-3
Rosuvastatin lactone

: 1431473-61-8
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-isopropylpyrimidin-5-yl]-3,5-dihydroxy-N-hydroxy-6-heptenamide

Guidance literature:: With magnesium(II) bromide; hydroxylamine hydrochloride; sodium hydrogencarbonate; In tetrahydrofuran; methanol; at 20 ℃; for 6h;

Reference yield:

: crestor

: 1431473-61-8
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-isopropylpyrimidin-5-yl]-3,5-dihydroxy-N-hydroxy-6-heptenamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water; acetonitrile / 0 - 5 °C / pH 4 / Darkness

1.2: 4 h / Reflux; Dean-Stark; Darkness

2.1: hydroxylamine / tetrahydrofuran; water / 2.5 h / 20 °C / Darkness

With hydrogenchloride; hydroxylamine; In tetrahydrofuran; water; acetonitrile;