503610-43-3Relevant articles and documents
Preparation method of rosuvastatin calcium
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, (2019/07/05)
The invention provides a preparation method of rosuvastatin calcium. A rosuvastatin calcium side chain is prepared by using allene as a raw material and is used to synthesize rosuvastatin calcium. According to the method, a hydrogen peroxide-heteropoly acid oxidation system is used to oxidize the side chain from olefin to aldehyde, thereby avoiding harsh conditions of low-temperature reaction in the prior art and being more beneficial to industrial production.
Palladium-Catalyzed Stereoselective Cyclization of in Situ Formed Allenyl Hemiacetals: Synthesis of Rosuvastatin and Pitavastatin
Spreider, Pierre A.,Breit, Bernhard
supporting information, p. 3286 - 3290 (2018/06/11)
A diastereoselective palladium-catalyzed cyclization of allenyl hemiacetals is described. It permits the selective synthesis of 1,3-dioxane derivatives, precursors for syn-configured 1,3-diols which make an appearance in all of the statin representatives. The reaction allows the total synthesis of Rosuvastatin and Pitavastatin in a straightforward fashion.
ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF
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Paragraph 0490; 0491, (2016/12/22)
An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.