4-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-piperidine-2,6-dione

Base Information

Chemical Name:4-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-piperidine-2,6-dione
CAS No.:102040-89-1
Molecular Formula:C₂₈H₃₅NO₅Si
Molecular Weight:493.675
Hs Code.:

Synonyms:4-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-piperidine-2,6-dione

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Chemical Property of 4-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-piperidine-2,6-dione

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Technology Process of 4-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-piperidine-2,6-dione

There total 5 articles about 4-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-piperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 144-48-9
iodacetamide

: 102040-85-7
(E)-3-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-acrylic acid methyl ester

: 102040-89-1
4-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-piperidine-2,6-dione

: 102040-90-4
3-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-4-carbamoyl-butyric acid methyl ester

Guidance literature:: With tri-n-butyl-tin hydride; In ethanol; toluene; at 90 - 120 ℃; for 15h; Heating; Irradiation; 1.) ethanol , 90 grad C , irradiation , under N₂ ; 2.) toluene ; 120 grad C;
DOI:10.1016/S0040-4039(01)80908-4

Reference yield:

: 102040-88-0
3-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-pentanedioic acid

: 102040-89-1
4-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-piperidine-2,6-dione

Guidance literature:: With urea; at 165 ℃; Yield given; Heating;
DOI:10.1016/S0040-4039(01)80908-4

Reference yield:

: 102040-85-7
(E)-3-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-acrylic acid methyl ester

: 102040-89-1
4-[(3aR,5R,6S,6aS)-6-(tert-Butyl-diphenyl-silanyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

3: LiOH

4: urea / 165 °C / Heating

With lithium hydroxide; urea;
DOI:10.1016/S0040-4039(01)80908-4