methyl 3-(1,3-bis(4-chlorophenyl)-3-(4-(3-methoxy-3-oxopropyl)-3,5-dimethyl-1H-pyrrol-2-yl)-1,5,7-trimethyl-2,3-dihydro-1H-pyrrolizin-6-yl)propanoate

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Chemical Name:methyl 3-(1,3-bis(4-chlorophenyl)-3-(4-(3-methoxy-3-oxopropyl)-3,5-dimethyl-1H-pyrrol-2-yl)-1,5,7-trimethyl-2,3-dihydro-1H-pyrrolizin-6-yl)propanoate
CAS No.:1338798-44-9
Molecular Formula:C₃₆H₄₀Cl₂N₂O₄
Molecular Weight:635.631
Hs Code.:

Synonyms:methyl 3-(1,3-bis(4-chlorophenyl)-3-(4-(3-methoxy-3-oxopropyl)-3,5-dimethyl-1H-pyrrol-2-yl)-1,5,7-trimethyl-2,3-dihydro-1H-pyrrolizin-6-yl)propanoate

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Chemical Property of methyl 3-(1,3-bis(4-chlorophenyl)-3-(4-(3-methoxy-3-oxopropyl)-3,5-dimethyl-1H-pyrrol-2-yl)-1,5,7-trimethyl-2,3-dihydro-1H-pyrrolizin-6-yl)propanoate

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Technology Process of methyl 3-(1,3-bis(4-chlorophenyl)-3-(4-(3-methoxy-3-oxopropyl)-3,5-dimethyl-1H-pyrrol-2-yl)-1,5,7-trimethyl-2,3-dihydro-1H-pyrrolizin-6-yl)propanoate

There total 2 articles about methyl 3-(1,3-bis(4-chlorophenyl)-3-(4-(3-methoxy-3-oxopropyl)-3,5-dimethyl-1H-pyrrol-2-yl)-1,5,7-trimethyl-2,3-dihydro-1H-pyrrolizin-6-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 99-91-2
para-chloroacetophenone

: 54474-51-0
methyl 2,4-dimethyl-3-pyrrolepropionate

: 1338798-44-9
methyl 3-(1,3-bis(4-chlorophenyl)-3-(4-(3-methoxy-3-oxopropyl)-3,5-dimethyl-1H-pyrrol-2-yl)-1,5,7-trimethyl-2,3-dihydro-1H-pyrrolizin-6-yl)propanoate

Guidance literature:: para-chloroacetophenone; methyl 2,4-dimethyl-3-pyrrolepropionate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water; optical yield given as %de; Saturated solution;
DOI:10.1021/ol202457n

Reference yield:

: 1338798-45-0
C₁₅H₂₃NO₄

: 1338798-44-9
methyl 3-(1,3-bis(4-chlorophenyl)-3-(4-(3-methoxy-3-oxopropyl)-3,5-dimethyl-1H-pyrrol-2-yl)-1,5,7-trimethyl-2,3-dihydro-1H-pyrrolizin-6-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 0.17 h

2.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C / Inert atmosphere

2.2: Saturated solution

With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ol202457n