54474-51-0

Basic information

• Product Name: 1H-Pyrrole-3-propanoic acid, 2,4-dimethyl-, methyl ester
• Synonyms: methyl 3-(2,4-dimethyl-1H-pyrrol-3-yl) propanoate;methyl 2,4-dimethyl-1H-pyrrole-3-propanoate;1H-Pyrrole-3-propanoic acid,2,4-dimethyl-,methyl ester;3-(2,4-dimethyl-pyrrol-3-yl)-propionic acid methyl ester;3-(2,4-dimethyl-1H-pyrrol-3-yl)propionic acid methyl ester;3-(2-methoxycarbonylethyl)-2,4-dimethylpyrrole;methyl 2,4-dimethyl-3-pyrrolepropionate
• CAS NO: 54474-51-0
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• Mol File: 54474-51-0.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-propanoic acid, 2,4-dimethyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-propanoic acid, 2,4-dimethyl-, methyl ester(54474-51-0)
• EPA Substance Registry System: 1H-Pyrrole-3-propanoic acid, 2,4-dimethyl-, methyl ester(54474-51-0)

Safety Data

• Hazardous Substances Data: 54474-51-0(Hazardous Substances Data)

Usage

Methyl ester of 1H-Pyrrole-3-propanoic acid

This indicates that the compound is derived from 1H-Pyrrole-3-propanoic acid and has a methyl ester group attached.

Two methyl groups at the 2 and 4 positions of the pyrrole ring

This describes the specific structure of the compound, with two methyl groups attached to the second and fourth carbon atoms of the pyrrole ring.

Used in organic synthesis and pharmaceutical research

This indicates the potential applications of the compound in the field of chemistry and drug development.

Potential biological activity

This suggests that the compound may have effects on living organisms, which could be relevant for drug development or other applications.

Applications in the development of new drugs or as a building block in chemical synthesis

This describes potential specific uses of the compound in the development of new pharmaceuticals or in the synthesis of other chemical compounds.

Properties and uses may vary depending on the specific application or research context

This indicates that the exact properties and potential uses of the compound may be dependent on the specific context in which it is being used or studied.

Upstream product

• 13306-30-4 coproporphyrin lV tetramethyl ester 
• 1338798-45-0 C₁₅H₂₃NO₄ 
• 67-56-1 methanol 
• 1263-63-4 mesoporphyrin IX DME 
• 13219-76-6 4-<2-(methoxycarbonyl)ethyl>-3,5-dimethylpyrrole-2-carboxylic acid 
• 62222-14-4 meso-porphyrin-II-dimethyl ester 
• 2644-60-2 χ-phylloporphyrin-XV 
• 20303-31-5 benzyl 4-(2-methoxycarbonylethyl)-3,5-dimethylpyrrole-2-carboxylate 
• 17106-07-9 4-ethyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid 

Downstream Products

• 124158-28-7 2,5-bis-[4-(2-methoxycarbonyl-ethyl)-3,5-dimethyl-pyrrol-2-yl]-[1,4]benzoquinone 
• 16132-20-0 tert-butyl 3,5-dimethyl-4-(2-methoxycarbonylethyl)-1H-pyrrole-2-carboxylate 
• 1333325-69-1 1,3,5,7-tetramethyl-2,6-bis(2-methoxycarbonylethyl)-8-[4-(N-ethyl-N-methylamino)phenyl]-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene 
• 1000870-50-7 1,3,5,7-tetramethyl-2,6-bis(2-methoxycarbonylethyl)-8-phenyl-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene 
• 1000870-47-2 1,3,5,7-tetramethyl-2,6-bis(2-methoxycarbonylethyl)-8-[4-(N,N-diethylamino)phenyl]-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene 
• 1000870-44-9 1,3,5,7-tetramethyl-2,6-bis(2-methoxycarbonylethyl)-8-[4-(N,N-dimethylamino)phenyl]-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene 
• 1333325-61-3 C₃₉H₅₁BF₂N₈O₈ 
• 1333325-62-4 C₄₀H₅₃BF₂N₈O₈ 
• 1333325-63-5 C₄₁H₅₅BF₂N₈O₈ 
• 1333325-64-6 C₃₇H₄₆BF₂N₇O₈ 
• 1000870-45-0 bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-dimethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) 
• 1333325-70-4 1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-[4-(N-ethyl-N-methylamino)phenyl]-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene 
• 1000870-48-3 bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-diethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) 
• 864969-59-5 bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-phenyl-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) 

Relevant articles and documents

Ligand-Directed Approach to Activity-Based Sensing: Developing Palladacycle Fluorescent Probes That Enable Endogenous Carbon Monoxide Detection

Carbon monoxide (CO) is an emerging gasotransmitter and reactive carbon species with broad anti-inflammatory, cytoprotective, and neurotransmitter functions along with therapeutic potential for the treatment of cardiovascular diseases. The study of CO chemistry in biology and medicine relative to other prominent gasotransmitters such as NO and H2S remains challenging, in large part due to limitations in available tools for the direct visualization of this transient and freely diffusing small molecule in complex living systems. Here we report a ligand-directed activity-based sensing (ABS) approach to CO detection through palladium-mediated carbonylation chemistry. Specifically, the design and synthesis of a series of ABS probes with systematic alterations in the palladium-ligand environment (e.g., sp3-S, sp3-N, sp2-N) establish structure-activity relationships for palladacycles to confer selective reactivity with CO under physiological conditions. These fundamental studies led to the development of an optimized probe, termed Carbon Monoxide Probe-3 Ester Pyridine (COP-3E-Py), which enables imaging of CO release in live cell and brain settings, including monitoring of endogenous CO production that triggers presynaptic dopamine release in fly brains. This work provides a unique tool for studying CO in living systems and establishes the utility of a synthetic methods approach to activity-based sensing using principles of organometallic chemistry.

One-pot synthesis of asymmetric annulated bis(pyrrole)s

Condensation of activated functionalized pyrroles with acetone results in asymmetric bis(pyrrole)s, formed via ring annulation. The methodology is somewhat general and can be applied to a variety of ketones, as well as to a range of pyrrolic substrates that do not bear electron-withdrawing groups directly adjacent to the pyrrole ring.

5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases

NP506, the 3-{2,4-dimethyl-5-[2-oxo-5-(N′-phenylhydrazinocarbonyl)-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid, was designed as FGF receptor 1 inhibitor by computational study and found to be more active against endothelial proliferation of HUVEC after the rhFGF-2 stimulation than SU6668 with minimum effective dose of 10 μM. NP506 inhibited the tyrosine phosphorylation in FGF, VEGF, and PDGF receptors and the activation of extracellular signal-regulated kinase (ERK), c-Jun-N-terminal-kinase (JNK) and AKT after the rhFGF-2 stimulation. The introduction of the phenyl hydrazide motif to the position 5 of the pyrido[2,3-d]pyrimidine scaffold led to the inhibitory effect in two signaling pathways: inhibition of AKT activation in the phosphatidyl inositol 3′-kinase (PI13K)/AKT signaling pathway and the inhibition of ERK and JNK activation in MAPK pathway.