3-(1H-indol-3-yl)-4-(1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl)-N-methylmaleimide

Base Information

Chemical Name:3-(1H-indol-3-yl)-4-(1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl)-N-methylmaleimide
CAS No.:1359754-66-7
Molecular Formula:C₂₄H₂₁N₅O₂
Molecular Weight:411.463
Hs Code.:

Synonyms:3-(1H-indol-3-yl)-4-(1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl)-N-methylmaleimide

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Chemical Property of 3-(1H-indol-3-yl)-4-(1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl)-N-methylmaleimide

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Technology Process of 3-(1H-indol-3-yl)-4-(1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl)-N-methylmaleimide

There total 5 articles about 3-(1H-indol-3-yl)-4-(1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl)-N-methylmaleimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27126-20-1
(3-azidopropyl)benzene

: C₁₅H₁₀N₂O₂

: 1359754-66-7
3-(1H-indol-3-yl)-4-(1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl)-N-methylmaleimide

Guidance literature:: With copper(ll) sulfate pentahydrate; ascorbic acid sodium salt; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1039/c1cc15851a

Reference yield:

: 174574-69-7
4-chloro-3-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione

: 1359754-66-7
3-(1H-indol-3-yl)-4-(1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl)-N-methylmaleimide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran; methanol

3: copper(ll) sulfate pentahydrate; ascorbic acid sodium salt / tetrahydrofuran; methanol / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(ll) sulfate pentahydrate; ascorbic acid sodium salt; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; methanol; 1: Sonogashira coupling;
DOI:10.1039/c1cc15851a

Reference yield:

: 1123-61-1
3,4-dichloro-1-methyl-pyrrole-2,5-dione

: 1359754-66-7
3-(1H-indol-3-yl)-4-(1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl)-N-methylmaleimide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 1 h / 60 °C

1.2: 1 h / 65 °C

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran; methanol

4.1: copper(ll) sulfate pentahydrate; ascorbic acid sodium salt / tetrahydrofuran; methanol / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(ll) sulfate pentahydrate; ascorbic acid sodium salt; ethylmagnesium bromide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; methanol; 2.1: Sonogashira coupling;
DOI:10.1039/c1cc15851a