1-[(Z)-1-Ethoxycarbonyl-2-methylsulfanyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-vinyl]-pyridinium; bromide

Base Information

• Chemical Name: 1-[(Z)-1-Ethoxycarbonyl-2-methylsulfanyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-vinyl]-pyridinium; bromide
• CAS No.: 96492-71-6
• Molecular Formula: Br*C₁₉H₂₀NO₃S₂
• Molecular Weight: 454.409
• Mol file: 96492-71-6.mol

Synonyms:1-[(Z)-1-Ethoxycarbonyl-2-methylsulfanyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-vinyl]-pyridinium; bromide

Chemical Property of 1-[(Z)-1-Ethoxycarbonyl-2-methylsulfanyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-vinyl]-pyridinium; bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(Z)-1-Ethoxycarbonyl-2-methylsulfanyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-vinyl]-pyridinium; bromide

There total 1 articles about 1-[(Z)-1-Ethoxycarbonyl-2-methylsulfanyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-vinyl]-pyridinium; bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-bromoacetophenone (70-11-1) + 1-pyridinio<>methylide> → 1-[(Z)-1-Ethoxycarbonyl-2-methylsulfanyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-vinyl]-pyridinium; bromide (96492-71-6)

Guidance literature:

In chloroform; Yield given; Ambient temperature;

DOI:10.1246/bcsj.60.1867

Reference yield: 80.0%

1-[(Z)-1-Ethoxycarbonyl-2-methylsulfanyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-vinyl]-pyridinium; bromide (96492-71-6) → (1S,9aR)-1-Benzoyl-3-methylsulfanyl-1,9a-dihydro-pyrido[2,1-c][1,4]thiazine-4-carboxylic acid ethyl ester (96492-81-8,96492-82-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In chloroform; at 0 ℃;

Reference yield:

1-[(Z)-1-Ethoxycarbonyl-2-methylsulfanyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-vinyl]-pyridinium; bromide (96492-71-6) → 1-Benzoylsulfanyl-2-methylsulfanyl-indolizine-3-carboxylic acid ethyl ester (112586-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CHCl₃ / 0.17 h / 0 °C

2: 68 percent / 2,3-dichloro-5,6-dicyano-p-benzoquinone / CHCl₃ / 6 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chloroform;

DOI:10.1246/bcsj.60.1867

upstream raw materials:

α-bromoacetophenone

Downstream raw materials:

(1S,9aR)-1-Benzoyl-3-methylsulfanyl-1,9a-dihydro-pyrido[2,1-c][1,4]thiazine-4-carboxylic acid ethyl ester

1-Benzoylsulfanyl-2-methylsulfanyl-indolizine-3-carboxylic acid ethyl ester