3-bromo-4-(2-bromovinyl)benzoic acid methyl ester

Base Information

• Chemical Name: 3-bromo-4-(2-bromovinyl)benzoic acid methyl ester
• CAS No.: 1129606-97-8
• Molecular Formula: C₁₀H₈Br₂O₂
• Molecular Weight: 319.98
• Mol file: 1129606-97-8.mol

Synonyms:3-bromo-4-(2-bromovinyl)benzoic acid methyl ester

Chemical Property of 3-bromo-4-(2-bromovinyl)benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-bromo-4-(2-bromovinyl)benzoic acid methyl ester

There total 2 articles about 3-bromo-4-(2-bromovinyl)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-bromo-4-(2,2-dibromovinyl)-methylbenzoate (1129606-94-5) → 3-bromo-4-(2-bromovinyl)benzoic acid methyl ester (1129606-97-8)

Guidance literature:

With dimethylphosphoric acid; triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 16h;

DOI:10.1039/b817254d

Reference yield:

3-bromo-4-formyl-benzoic acid methyl ester (90484-53-0) + (bromomethyl)triphenyl phosphonium bromide (1034-49-7) → 3-bromo-4-(2-bromovinyl)benzoic acid methyl ester (1109244-73-6) + 3-bromo-4-(2-bromovinyl)benzoic acid methyl ester (1129606-97-8)

Guidance literature:

(bromomethyl)triphenyl phosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 1.5h; Inert atmosphere;

3-bromo-4-formyl-benzoic acid methyl ester; In tetrahydrofuran; at -78 - 20 ℃; for 16h; optical yield given as %de; Inert atmosphere;

DOI:10.1021/ol802624e

Reference yield: 70.0%

tert-butyl carbazate (4248-19-5) + 3-bromo-4-(2-bromovinyl)benzoic acid methyl ester (1129606-97-8) → indole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester (354587-63-6)

Guidance literature:

With potassium phosphate; copper (I) acetate; N,N`-dimethylethylenediamine; In toluene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1039/b817254d

upstream raw materials:

3-bromo-4-formyl-benzoic acid methyl ester

(bromomethyl)triphenyl phosphonium bromide

3-bromo-4-(2,2-dibromovinyl)-methylbenzoate

Downstream raw materials:

indole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester