(2S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-amine

Base Information

Chemical Name:(2S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-amine
CAS No.:1187832-27-4
Molecular Formula:C₁₉H₃₂N₂O
Molecular Weight:304.476
Hs Code.:

Synonyms:(2S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-amine

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Chemical Property of (2S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-amine

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Technology Process of (2S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-amine

There total 4 articles about (2S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1187832-42-3
C₂₄H₃₈N₂O₄

: 1187832-27-4
(2S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-amine

Guidance literature:: C₂₄H₃₈N₂O₄; With diborane; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 2h; Reflux;

With sodium carbonate; In water;

Reference yield: 100.0%

: 1318792-43-6
C₂₄H₄₀N₂O₃

: 1187832-27-4
(2S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-amine

Guidance literature:: C₂₄H₄₀N₂O₃; With diborane; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; for 2h; Reflux;

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 1187832-27-4
(2S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 4 h / 20 °C

2.1: diborane / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

2.2: 2 h / 20 °C / Reflux

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; diborane; In tetrahydrofuran;