(S)-2-[((5S,6S,9R,14aS)-5-Amino-6-methyl-4,11,14-trioxo-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carbonyl)-amino]-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester; hydrochloride

Base Information

Chemical Name:(S)-2-[((5S,6S,9R,14aS)-5-Amino-6-methyl-4,11,14-trioxo-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carbonyl)-amino]-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester; hydrochloride
CAS No.:116823-43-9
Molecular Formula:C₃₂H₄₈N₆O₈S*ClH
Molecular Weight:713.295
Hs Code.:

(S)-2-[((5S,6S,9R,14aS)-5-Amino-6-methyl-4,11,14-trioxo-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carbonyl)-amino]-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester; hydrochloride

Synonyms:(S)-2-[((5S,6S,9R,14aS)-5-Amino-6-methyl-4,11,14-trioxo-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carbonyl)-amino]-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester; hydrochloride

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Chemical Property of (S)-2-[((5S,6S,9R,14aS)-5-Amino-6-methyl-4,11,14-trioxo-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carbonyl)-amino]-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester; hydrochloride

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Technology Process of (S)-2-[((5S,6S,9R,14aS)-5-Amino-6-methyl-4,11,14-trioxo-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carbonyl)-amino]-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester; hydrochloride

There total 3 articles about (S)-2-[((5S,6S,9R,14aS)-5-Amino-6-methyl-4,11,14-trioxo-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carbonyl)-amino]-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116823-42-8
(S)-6-Benzyloxycarbonylamino-2-{[(5S,6S,9R)-6-methyl-4,11,14-trioxo-5-(2,2,2-trichloro-ethoxycarbonylamino)-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carbonyl]-amino}-hexanoic acid tert-butyl ester

: 116823-43-9
(S)-2-[((5S,6S,9R)-5-Amino-6-methyl-4,11,14-trioxo-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carbonyl)-amino]-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; acetic acid; zinc; Yield given. Multistep reaction;
DOI:10.1016/S0040-4039(00)80212-9

Reference yield:

: 116823-41-7
(5S,6S,9R)-6-Methyl-4,11,14-trioxo-5-(2,2,2-trichloro-ethoxycarbonylamino)-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carboxylic acid

: 116823-43-9
(S)-2-[((5S,6S,9R)-5-Amino-6-methyl-4,11,14-trioxo-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carbonyl)-amino]-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 1-ethyl-3-(3-dimethylamino-propyl)-carbodiimide, 1-hydroxybenzotriazole

2: 1.) Zn/AcOH; 2.) HCl

With hydrogenchloride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; zinc;
DOI:10.1016/S0040-4039(00)80212-9

Reference yield:

: 116823-40-6
(5S,6S,9R)-5-tert-Butoxycarbonylamino-6-methyl-4,11,14-trioxo-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carboxylic acid benzyl ester

: 116823-43-9
(S)-2-[((5S,6S,9R)-5-Amino-6-methyl-4,11,14-trioxo-dodecahydro-7-thia-3a,10,13-triaza-cyclopentacyclotridecene-9-carbonyl)-amino]-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) HF / 1.) anisole

2: 90 percent / 1-ethyl-3-(3-dimethylamino-propyl)-carbodiimide, 1-hydroxybenzotriazole

3: 1.) Zn/AcOH; 2.) HCl

With hydrogenchloride; hydrogen fluoride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; zinc;
DOI:10.1016/S0040-4039(00)80212-9