Technology Process of [5-chloro-2-(propan-2-yl)phenyl]boronic acid
There total 4 articles about [5-chloro-2-(propan-2-yl)phenyl]boronic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-chloro-2-iodo-1-(propan-2-yl)benzene;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at -30 ℃;
for 0.5h;
Inert atmosphere;
Trimethyl borate;
In
tetrahydrofuran;
at -30 ℃;
for 1.5h;
With
hydrogenchloride; water;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: nitric acid / sulfuric acid / 1 h / -5 - 10 °C
1.2: pH 7
2.1: hydrogenchloride; sodium nitrite / water / 1.5 h / 0 °C
2.2: 2 h / 20 - 80 °C
3.1: hydrazine hydrate; iron(III) chloride / methanol / 7 h / Reflux
4.1: toluene-4-sulfonic acid; sodium nitrite / water / 0.17 h
4.2: 0.33 h
5.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -30 °C / Inert atmosphere
5.2: 1.5 h / -30 °C
With
hydrogenchloride; iron(III) chloride; isopropylmagnesium chloride; nitric acid; toluene-4-sulfonic acid; hydrazine hydrate; sodium nitrite;
sulfuric acid;
In
tetrahydrofuran; methanol; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid; sodium nitrite / water / 0.17 h
1.2: 0.33 h
2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -30 °C / Inert atmosphere
2.2: 1.5 h / -30 °C
With
isopropylmagnesium chloride; toluene-4-sulfonic acid; sodium nitrite;
In
tetrahydrofuran; water;
