C₁₅H₁₂INO

Base Information

• Chemical Name: C₁₅H₁₂INO
• CAS No.: 174770-49-1
• Molecular Formula: C₁₅H₁₂INO
• Molecular Weight: 349.171
• Mol file: 174770-49-1.mol

Synonyms:C₁₅H₁₂INO

Chemical Property of C₁₅H₁₂INO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₂INO

There total 3 articles about C₁₅H₁₂INO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C15H14INO2 (1131379-89-9) → C15H12INO (174770-49-1)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); diisopropyl-carbodiimide; In 1,4-dioxane; at 20 ℃; for 5h; Inert atmosphere; Reflux;

DOI:10.1021/ol8029092

Reference yield:

2-Iodobenzoyl chloride (609-67-6) + D-2-phenylglycinol (56613-80-0) → C15H12INO (174770-49-1)

Guidance literature:

2-Iodobenzoyl chloride; D-2-phenylglycinol; With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

With methanesulfonyl chloride; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.organomet.6b00069

Reference yield:

2-Iodobenzoic acid (88-67-5) → C15H12INO (174770-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere; Schlenk technique; Cooling

2.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere; Schlenk technique

2.2: 16 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/acs.organomet.6b00069

upstream raw materials:

C₁₅H₁₄INO₂

2-Iodobenzoic acid

2-Iodobenzoyl chloride

D-2-phenylglycinol

Downstream raw materials:

C₁₅H₁₂INO₃