(2S,3S,4S)-3-Methoxycarbonylmethyl-4-(1-methyl-3-oxo-2-phenylselanyl-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Base Information

Chemical Name:(2S,3S,4S)-3-Methoxycarbonylmethyl-4-(1-methyl-3-oxo-2-phenylselanyl-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
CAS No.:81658-35-7
Molecular Formula:C₂₄H₃₃NO₇Se
Molecular Weight:526.489
Hs Code.:

(2S,3S,4S)-3-Methoxycarbonylmethyl-4-(1-methyl-3-oxo-2-phenylselanyl-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Synonyms:(2S,3S,4S)-3-Methoxycarbonylmethyl-4-(1-methyl-3-oxo-2-phenylselanyl-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

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Chemical Property of (2S,3S,4S)-3-Methoxycarbonylmethyl-4-(1-methyl-3-oxo-2-phenylselanyl-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,3S,4S)-3-Methoxycarbonylmethyl-4-(1-methyl-3-oxo-2-phenylselanyl-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

There total 6 articles about (2S,3S,4S)-3-Methoxycarbonylmethyl-4-(1-methyl-3-oxo-2-phenylselanyl-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81658-31-3
(2S,3S,4S)-4-(1-[1,3]Dioxolan-2-yl-ethyl)-3-(2-hydroxy-ethyl)-2-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 81658-35-7
(2S,3S,4S)-3-Methoxycarbonylmethyl-4-(1-methyl-3-oxo-2-phenylselanyl-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) pyridinium dichromate / 1.) DMF, 40 deg C, 48 h

2: 64 percent / 60percent AcOH / 24 h / 60 °C

3: t-AmONa / benzene / 0.5 h / Ambient temperature

4: Et₃N / tetrahydrofuran; H₂O / 1 h / Ambient temperature

With dipyridinium dichromate; sodium tert-pentoxide; acetic acid; triethylamine; In tetrahydrofuran; water; benzene;
DOI:10.1021/ja00376a048

Reference yield:

: 81658-33-5,81802-31-5,88115-70-2,88196-37-6
(2S,3S,4S)-1-tert-butyl 2-methyl 3-(2-methoxy-2-oxoethyl)-4-((R)-1-oxopropan-2-yl)pyrrolidine-1,2-dicarboxylate

: 81658-35-7
(2S,3S,4S)-3-Methoxycarbonylmethyl-4-(1-methyl-3-oxo-2-phenylselanyl-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: t-AmONa / benzene / 0.5 h / Ambient temperature

2: Et₃N / tetrahydrofuran; H₂O / 1 h / Ambient temperature

With sodium tert-pentoxide; triethylamine; In tetrahydrofuran; water; benzene;
DOI:10.1021/ja00376a048

Reference yield:

: 81802-30-4
(2S,3S,4S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(1-[1,3]dioxolan-2-yl-ethyl)-3-(2-hydroxy-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 81658-35-7
(2S,3S,4S)-3-Methoxycarbonylmethyl-4-(1-methyl-3-oxo-2-phenylselanyl-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: MeOH - p-TsOH / 3 h / Ambient temperature

2: 1.) pyridinium dichromate / 1.) DMF, 40 deg C, 48 h

3: 64 percent / 60percent AcOH / 24 h / 60 °C

4: t-AmONa / benzene / 0.5 h / Ambient temperature

5: Et₃N / tetrahydrofuran; H₂O / 1 h / Ambient temperature

With methanol; dipyridinium dichromate; sodium tert-pentoxide; toluene-4-sulfonic acid; acetic acid; triethylamine; In tetrahydrofuran; water; benzene;
DOI:10.1021/ja00376a048