(1R,1'R,3'R,4'aR,5S,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]-1'-vinylspiro(2-cyclopentene-1,2'(1'H)-naphthalene)-1'ol

Base Information

Chemical Name:(1R,1'R,3'R,4'aR,5S,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]-1'-vinylspiro(2-cyclopentene-1,2'(1'H)-naphthalene)-1'ol
CAS No.:196939-46-5
Molecular Formula:C₃₃H₅₂O₅Si
Molecular Weight:556.858
Hs Code.:

(1R,1'R,3'R,4'aR,5S,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]-1'-vinylspiro(2-cyclopentene-1,2'(1'H)-naphthalene)-1'ol

Synonyms:(1R,1'R,3'R,4'aR,5S,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]-1'-vinylspiro(2-cyclopentene-1,2'(1'H)-naphthalene)-1'ol

Suppliers and Price of (1R,1'R,3'R,4'aR,5S,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]-1'-vinylspiro(2-cyclopentene-1,2'(1'H)-naphthalene)-1'ol

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Chemical Property of (1R,1'R,3'R,4'aR,5S,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]-1'-vinylspiro(2-cyclopentene-1,2'(1'H)-naphthalene)-1'ol

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Technology Process of (1R,1'R,3'R,4'aR,5S,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]-1'-vinylspiro(2-cyclopentene-1,2'(1'H)-naphthalene)-1'ol

There total 5 articles about (1R,1'R,3'R,4'aR,5S,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]-1'-vinylspiro(2-cyclopentene-1,2'(1'H)-naphthalene)-1'ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 186087-73-0
(1R,1'R,3'R,4'aR,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]-1'-vinylspiro(2-cyclopentene-1,2'(1'H)-naphthalene)-1',3'-diol

: 74-88-4
methyl iodide

: 196939-46-5
(1R,1'R,3'R,4'aR,5S,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]-1'-vinylspiro(2-cyclopentene-1,2'(1'H)-naphthalene)-1'ol

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 24h;
DOI:10.1021/ja971527n

Reference yield:

: 186087-72-9
C₃₂H₄₈O₅Si

: 196939-46-5
(1R,1'R,3'R,4'aR,5S,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]-1'-vinylspiro(2-cyclopentene-1,2'(1'H)-naphthalene)-1'ol

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 2 h / -78 °C

2: 79 percent / NaH / tetrahydrofuran / 24 h

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ja971527n

Reference yield:

: 184637-30-7
C₃₀H₄₆O₅Si

: 196939-46-5
(1R,1'R,3'R,4'aR,5S,6'S,8'aR)-3',4',4'a,5',6',7',8',8'a-octahydro-3'-methoxy-6'-[(p-methoxybenzyl)oxy]-5',5',8'a-trimethyl-5-[2-(trimethylsilyl)ethoxy]-1'-vinylspiro(2-cyclopentene-1,2'(1'H)-naphthalene)-1'ol

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / tetrahydrofuran / 12 h / 20 °C

2: Dess-Martin periodinane reagent / CH₂Cl₂; pyridine / 2 h

3: LiAlH₄ / tetrahydrofuran / 2 h / -78 °C

4: 79 percent / NaH / tetrahydrofuran / 24 h

With lithium aluminium tetrahydride; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1021/ja971527n