methyl (2-fluoro-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

Base Information

Chemical Name:methyl (2-fluoro-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate
CAS No.:361336-92-7
Molecular Formula:C₁₀H₇F₄NO₇S
Molecular Weight:361.228
Hs Code.:

Synonyms:methyl (2-fluoro-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

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Chemical Property of methyl (2-fluoro-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

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Technology Process of methyl (2-fluoro-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

There total 5 articles about methyl (2-fluoro-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 361340-51-4
methyl (2-fluoro-6-hydroxy-3-nitrophenyl)acetate

: 361336-92-7
methyl (2-fluoro-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm030233b

Reference yield:

: 85068-28-6
2,6-difluorophenylacetic acid

: 361336-92-7
methyl (2-fluoro-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / HNO₃ / methanol / 0.25 h / -10 °C

2: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

3: 5.47 g / pyridine / CH₂Cl₂ / 20 °C

4: 27 percent / trimethylacetic acid; K₂CO₃ / dimethylsulfoxide / 0.25 h / 80 °C

5: 68 percent / Et₃N / CH₂Cl₂ / 20 °C

With pyridine; oxalyl dichloride; nitric acid; potassium carbonate; triethylamine; N,N-dimethyl-formamide; Trimethylacetic acid; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm030233b

Reference yield:

: (2,6-difluoro-3-nitro-phenyl)-acetyl chloride

: 361336-92-7
methyl (2-fluoro-3-nitro-6-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 5.47 g / pyridine / CH₂Cl₂ / 20 °C

2: 27 percent / trimethylacetic acid; K₂CO₃ / dimethylsulfoxide / 0.25 h / 80 °C

3: 68 percent / Et₃N / CH₂Cl₂ / 20 °C

With pyridine; potassium carbonate; triethylamine; Trimethylacetic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm030233b