{3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetic acid

Base Information

Chemical Name:{3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetic acid
CAS No.:361336-96-1
Molecular Formula:C₂₂H₂₀FNO₂
Molecular Weight:349.405
Hs Code.:

Synonyms:{3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetic acid

Suppliers and Price of {3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetic acid

There total 10 articles about {3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 361336-95-0
methyl {3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetate

: 361336-96-1
{3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetic acid

Guidance literature:: With sodium hydroxide; In methanol; at 65 ℃;
DOI:10.1021/jm030233b

Reference yield:

: 960-16-7
tributylphenylstannane

: 361336-96-1
{3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / (Ph₃P)4Pd; LiCl / dioxane / 85 °C

2: 91 percent / Fe; glacial AcOH / 80 °C

3: 80 percent / NaHB(OAc)3; AcOH / tetrahydrofuran; CH₂Cl₂ / 20 °C

4: 84 percent / aq. NaOH / methanol / 65 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tris(acetoxy)borohydride; iron; acetic acid; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 1: Stille coupling;
DOI:10.1021/jm030233b

Reference yield:

: 85068-28-6
2,6-difluorophenylacetic acid

: 361336-96-1
{3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 91 percent / HNO₃ / methanol / 0.25 h / -10 °C

2: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

3: 5.47 g / pyridine / CH₂Cl₂ / 20 °C

4: 27 percent / trimethylacetic acid; K₂CO₃ / dimethylsulfoxide / 0.25 h / 80 °C

5: 68 percent / Et₃N / CH₂Cl₂ / 20 °C

6: 78 percent / (Ph₃P)4Pd; LiCl / dioxane / 85 °C

7: 91 percent / Fe; glacial AcOH / 80 °C

8: 80 percent / NaHB(OAc)3; AcOH / tetrahydrofuran; CH₂Cl₂ / 20 °C

9: 84 percent / aq. NaOH / methanol / 65 °C

With pyridine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; nitric acid; sodium tris(acetoxy)borohydride; iron; potassium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide; lithium chloride; Trimethylacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; 6: Stille coupling;
DOI:10.1021/jm030233b