1,4-bis{[4-(3-methoxycarbonyl-4-oxotetrahydro-3-thienyl)methyl-[1,2,3]triazole-1-yl]methyl}benzene

Base Information

Chemical Name:1,4-bis{[4-(3-methoxycarbonyl-4-oxotetrahydro-3-thienyl)methyl-[1,2,3]triazole-1-yl]methyl}benzene
CAS No.:1417450-32-8
Molecular Formula:C₂₆H₂₈N₆O₆S₂
Molecular Weight:584.677
Hs Code.:

Synonyms:1,4-bis{[4-(3-methoxycarbonyl-4-oxotetrahydro-3-thienyl)methyl-[1,2,3]triazole-1-yl]methyl}benzene

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Chemical Property of 1,4-bis{[4-(3-methoxycarbonyl-4-oxotetrahydro-3-thienyl)methyl-[1,2,3]triazole-1-yl]methyl}benzene

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Technology Process of 1,4-bis{[4-(3-methoxycarbonyl-4-oxotetrahydro-3-thienyl)methyl-[1,2,3]triazole-1-yl]methyl}benzene

There total 3 articles about 1,4-bis{[4-(3-methoxycarbonyl-4-oxotetrahydro-3-thienyl)methyl-[1,2,3]triazole-1-yl]methyl}benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 102437-81-0
p-xylylene diazide

: 84782-85-4
methyl 4-oxo-3-(propargyl)tetrahydrothiophene-3-carboxylate

: 1417450-32-8
1,4-bis{[4-(3-methoxycarbonyl-4-oxotetrahydro-3-thienyl)methyl-[1,2,3]triazole-1-yl]methyl}benzene

Guidance literature:: With di-μ-hydroxo-bis[(N,N,N′,N′-tetramethylethylenediamine)copper(II)] chloride; In dichloromethane; at 23 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tet.2012.10.107

Reference yield:

: 623-25-6
p-Xylylene dichloride

: 1417450-32-8
1,4-bis{[4-(3-methoxycarbonyl-4-oxotetrahydro-3-thienyl)methyl-[1,2,3]triazole-1-yl]methyl}benzene

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / dimethyl sulfoxide / 1 h / 20 °C

2: di-μ-hydroxo-bis[(N,N,N′,N′-tetramethylethylenediamine)copper(II)] chloride / dichloromethane / 3 h / 23 °C / Inert atmosphere

With sodium azide; di-μ-hydroxo-bis[(N,N,N′,N′-tetramethylethylenediamine)copper(II)] chloride; In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tet.2012.10.107

Reference yield:

: 2689-68-1,99328-39-9
methyl 4-oxotetrahydrothiophene-3-carboxylate

: 1417450-32-8
1,4-bis{[4-(3-methoxycarbonyl-4-oxotetrahydro-3-thienyl)methyl-[1,2,3]triazole-1-yl]methyl}benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 0.17 h / 23 °C

1.2: 1 h / Reflux

2.1: di-μ-hydroxo-bis[(N,N,N′,N′-tetramethylethylenediamine)copper(II)] chloride / dichloromethane / 3 h / 23 °C / Inert atmosphere

With di-μ-hydroxo-bis[(N,N,N′,N′-tetramethylethylenediamine)copper(II)] chloride; potassium carbonate; In dichloromethane; acetone; 1.2: |Michael Addition;
DOI:10.1016/j.tet.2012.10.107