4-[3-(butylureido)benzoyl]-1-methylpiperidine

Base Information

Chemical Name:4-[3-(butylureido)benzoyl]-1-methylpiperidine
CAS No.:288157-80-2
Molecular Formula:C₁₈H₂₇N₃O₂
Molecular Weight:317.431
Hs Code.:

Synonyms:4-[3-(butylureido)benzoyl]-1-methylpiperidine

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Chemical Property of 4-[3-(butylureido)benzoyl]-1-methylpiperidine

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Technology Process of 4-[3-(butylureido)benzoyl]-1-methylpiperidine

There total 7 articles about 4-[3-(butylureido)benzoyl]-1-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 288156-90-1
4-[3-aminobenzoyl]-1-methylpiperidine

: 111-36-4
n-butyl isocyanide

: 288157-80-2
4-[3-(butylureido)benzoyl]-1-methylpiperidine

Guidance literature:: With poly(4-vinyl pyridine); In tetrahydrofuran; for 240h;

Reference yield:

: 68947-43-3
1-methylpiperidine-4-carboxylic acid

: 288157-80-2
4-[3-(butylureido)benzoyl]-1-methylpiperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 63 h

2.1: methyllithium; tert.-butyl lithium / tetrahydrofuran; pentane / 0.92 h / -78 °C

2.2: 21 h / -78 - 20 °C

3.1: hydrogenchloride / water / 1.75 h / Heating / reflux

3.2: 1 h

4.1: poly(4-vinyl pyridine) / tetrahydrofuran / 240 h

With hydrogenchloride; poly(4-vinyl pyridine); methyllithium; tert.-butyl lithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water; pentane;

Reference yield:

: 498-94-2
isonipecotic acid

: 288157-80-2
4-[3-(butylureido)benzoyl]-1-methylpiperidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / water / 18 h / 20 °C / 3102.97 Torr

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 63 h

3.1: methyllithium; tert.-butyl lithium / tetrahydrofuran; pentane / 0.92 h / -78 °C

3.2: 21 h / -78 - 20 °C

4.1: hydrogenchloride / water / 1.75 h / Heating / reflux

4.2: 1 h

5.1: poly(4-vinyl pyridine) / tetrahydrofuran / 240 h

With hydrogenchloride; poly(4-vinyl pyridine); methyllithium; hydrogen; tert.-butyl lithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water; pentane;