68947-43-3

Basic information

• Product Name: 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID
• Synonyms: 1-methylpiperidine-4-carboxylic acid(SALTDATA: HCl);4-Carboxy-1-methylpiperidine;1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID;N-METHYL-4-PIPERIDINE CARBOXYLIC ACID;N-METHYLPIPERIDINE-4-CARBOXYLIC ACID;N-Methylisonipecotic acid;1-METHYL-PIPERIDIN-4-CARBOXYLIC ACID;68947-43-3
• CAS NO: 68947-43-3
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18
• Product Categories: Piperidine;Carboxylic Acids;Pyrans, Piperidines & Piperazines
• Mol File: 68947-43-3.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 246.068 °C at 760 mmHg
• Flash Point: 102.619 °C
• Appearance: /
• Density: 1.103
• Vapor Pressure: 0.00899mmHg at 25°C
• Refractive Index: 1.488
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.16±0.20(Predicted)
• CAS DataBase Reference: 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID(68947-43-3)
• EPA Substance Registry System: 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID(68947-43-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 68947-43-3(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H13NO2/c1-8-4-2-6(3-5-8)7(9)10/h6H,2-5H2,1H3,(H,9,10)

Upstream product

• 64-18-6 formic acid 
• 590-29-4 potassium formate 
• 824-77-1 4-carboxy-1-methylpyridinium inner salt monohydrate 
• 1126-09-6 4-carbethoxypiperidine 
• 74-88-4 methyl iodide 
• 24252-37-7 ethyl 1-methylisonipecotate 
• 67-56-1 methanol 
• 498-94-2 isonipecotic acid 
• 20691-89-8 1-methyl-4-piperidinemethanol 
• 946493-45-4 N-methylisonipecotic acid sodium salt 
• 7630-02-6 4-(methoxycarbonyl)-1-methylpyridinium iodide 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 55-22-1 pyridine-4-carboxylic acid 
• 5746-18-9 1-methyl-4-carboxypyridinium chloride 

Downstream Products

• 24252-37-7 ethyl 1-methylisonipecotate 
• 92040-00-1 (1-methylpiperidin-4-yl)(phenyl)methanone 
• 101264-50-0 1-methyl-piperidine-4-carboxylic acid anilide 
• 122225-86-9 N-<(1-methylpiperidin-4-yl)carbonyl>-O-methyltyrosine benzyl ester 
• 489468-93-1 3-(2-chloroethyl)-1-methylpyrrolidin-2-one 
• 6071-92-7 VUF 4589 
• 215950-19-9 1-methyl-piperidine-4-carboxylic acid methoxy-methyl-amide 
• 7462-84-2 1-methylpiperidine-4-carbonyl chloride hydrochloride 
• 548770-31-6 methyl-phenyl-carbamic acid 4-{2-[(1-methyl-piperidine-4-carbonyl)-amino]-ethyl}-phenyl ester 
• 891263-95-9 C₂₈H₃₇N₅O₂ 
• 891263-97-1 C₂₈H₃₇N₅O₂ 
• 891263-91-5 C₂₈H₃₇N₅O₂ 
• 891263-93-7 C₂₈H₃₇N₅O₂ 
• 891263-89-1 C₂₉H₃₉N₅O₃ 

Relevant articles and documents

Electroactivated alkylation of amines with alcohols: Via both direct and indirect borrowing hydrogen mechanisms

A green, efficient N-alkylation of amines with simple alcohols has been achieved in aqueous solution via an electrochemical version of the so-called "borrowing hydrogen methodology". Catalyzed by Ru on activated carbon cloth (Ru/ACC), the reaction works well with methanol, and with primary and secondary alcohols. Alkylation can be accomplished by either of two different electrocatalytic processes: (1) in an undivided cell, alcohol (present in excess) is oxidized at the Ru/ACC anode; the aldehyde or ketone product condenses with the amine; and the resulting imine is reduced at an ACC cathode, combining with protons released by the oxidation. This process consumes stoichiometric quantities of current. (2) In a membrane-divided cell, the current-activated Ru/ACC cathode effects direct C-H activation of the alcohol; the resulting carbonyl species, either free or still surface-adsorbed, condenses with amine to form imine and is reduced as in (1). These alcohol activation processes can alkylate primary and secondary aliphatic amines, as well as ammonia itself at 25-70 °C and ambient pressure.

CONTROLLED RELEASE PREPARATION

A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.

THIAZOLIDINONE DERIVATIVE

An object of the present invention is to provide thiazolidinone derivatives. More specifically, an object of the present invention is to provide novel compounds having a CDC7 inhibitory action. The present invention provides thiazolidinone derivatives represented by the formula (I) The compounds of the present invention inhibit the CDC7 protein kinase activity, and suppress cell proliferation.