(R)-4-3'-diphenylmethyloxycarbonyl-3'-p-nitrobenzyloxycarbonyl-2'-oxopropyl-2-azetidinone

Base Information

Chemical Name:(R)-4-3'-diphenylmethyloxycarbonyl-3'-p-nitrobenzyloxycarbonyl-2'-oxopropyl-2-azetidinone
CAS No.:103841-71-0
Molecular Formula:C₂₈H₂₄N₂O₈
Molecular Weight:516.507
Hs Code.:

Synonyms:(R)-4-3'-diphenylmethyloxycarbonyl-3'-p-nitrobenzyloxycarbonyl-2'-oxopropyl-2-azetidinone

Suppliers and Price of (R)-4-3'-diphenylmethyloxycarbonyl-3'-p-nitrobenzyloxycarbonyl-2'-oxopropyl-2-azetidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-3'-diphenylmethyloxycarbonyl-3'-p-nitrobenzyloxycarbonyl-2'-oxopropyl-2-azetidinone

Chemical Property:

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Technology Process of (R)-4-3'-diphenylmethyloxycarbonyl-3'-p-nitrobenzyloxycarbonyl-2'-oxopropyl-2-azetidinone

There total 10 articles about (R)-4-3'-diphenylmethyloxycarbonyl-3'-p-nitrobenzyloxycarbonyl-2'-oxopropyl-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76144-16-6
5-methyl 1-hydrogen (S)-3-benzylaminoglutarate

: 103841-71-0
(R)-4-3'-diphenylmethyloxycarbonyl-3'-p-nitrobenzyloxycarbonyl-2'-oxopropyl-2-azetidinone

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 1.5 h / Ambient temperature

2: TEA / benzene / 3 h / Ambient temperature

3: 87 percent / 1 N NaOH / methanol; H₂O / 1 h / 0 °C

4: 1.) Na; 2.) 1 N HCl / 1.) liq. NH₃, 5 min; 2.) EtOH, RT, 1 h

5: 88 percent / H₂ / 5 percent Pd-C / ethanol / 1.5 h / Ambient temperature

6: 1.) isobutyl chloroformate, TEA; 2.) 50 percent NaH / 1.) THF, -20 deg C, 1 h; 2.) -5- 5 deg C, 1 h, THF

With hydrogenchloride; sodium hydroxide; thionyl chloride; TEA; hydrogen; sodium; sodium hydride; isobutyl chloroformate; palladium on activated charcoal; In methanol; ethanol; water; benzene;
DOI:10.1248/cpb.33.3299

Reference yield:

: 76144-17-7
(4R) N-Benzyl-4-methoxycarbonylmethyl-azetidin-2-one

: 103841-71-0
(R)-4-3'-diphenylmethyloxycarbonyl-3'-p-nitrobenzyloxycarbonyl-2'-oxopropyl-2-azetidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / 1 N NaOH / methanol; H₂O / 1 h / 0 °C

2: 1.) Na; 2.) 1 N HCl / 1.) liq. NH₃, 5 min; 2.) EtOH, RT, 1 h

3: 88 percent / H₂ / 5 percent Pd-C / ethanol / 1.5 h / Ambient temperature

4: 1.) isobutyl chloroformate, TEA; 2.) 50 percent NaH / 1.) THF, -20 deg C, 1 h; 2.) -5- 5 deg C, 1 h, THF

With hydrogenchloride; sodium hydroxide; TEA; hydrogen; sodium; sodium hydride; isobutyl chloroformate; palladium on activated charcoal; In methanol; ethanol; water;
DOI:10.1248/cpb.33.3299

Reference yield:

: 103841-69-6
(R)-N-benzyl-4-cyanomethyl-2-azetidinone

: 103841-71-0
(R)-4-3'-diphenylmethyloxycarbonyl-3'-p-nitrobenzyloxycarbonyl-2'-oxopropyl-2-azetidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 40 percent / HCl gas / 1.) 0 deg C, 10 min; 2.) RT, 1 h

2: 87 percent / 1 N NaOH / methanol; H₂O / 1 h / 0 °C

3: 1.) Na; 2.) 1 N HCl / 1.) liq. NH₃, 5 min; 2.) EtOH, RT, 1 h

4: 88 percent / H₂ / 5 percent Pd-C / ethanol / 1.5 h / Ambient temperature

5: 1.) isobutyl chloroformate, TEA; 2.) 50 percent NaH / 1.) THF, -20 deg C, 1 h; 2.) -5- 5 deg C, 1 h, THF

With hydrogenchloride; sodium hydroxide; TEA; hydrogen; sodium; sodium hydride; isobutyl chloroformate; palladium on activated charcoal; In methanol; ethanol; water;
DOI:10.1248/cpb.33.3299