(S_S,R_C)-diethyl [4-phenyl-2-(p-tolylsulfinylamino)buten-3-yl]phosphonate

Base Information

• Chemical Name: (S_S,R_C)-diethyl [4-phenyl-2-(p-tolylsulfinylamino)buten-3-yl]phosphonate
• CAS No.: 180906-45-0
• Molecular Formula: C₂₁H₂₈NO₄PS
• Molecular Weight: 421.497
• Mol file: 180906-45-0.mol

Synonyms:(S_S,R_C)-diethyl [4-phenyl-2-(p-tolylsulfinylamino)buten-3-yl]phosphonate

Chemical Property of (S_S,R_C)-diethyl [4-phenyl-2-(p-tolylsulfinylamino)buten-3-yl]phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S_S,R_C)-diethyl [4-phenyl-2-(p-tolylsulfinylamino)buten-3-yl]phosphonate

There total 1 articles about (S_S,R_C)-diethyl [4-phenyl-2-(p-tolylsulfinylamino)buten-3-yl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Diethyl methylphosphonate (683-08-9) + C16H15NOS (181136-73-2) → (SS,SC)-diethyl [4-phenyl-2-(p-tolylsulfinylamino)buten-3-yl]phosphonate (180906-44-9) + (SS,RC)-diethyl [4-phenyl-2-(p-tolylsulfinylamino)buten-3-yl]phosphonate (180906-45-0)

Guidance literature:

Diethyl methylphosphonate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

C₁₆H₁₅NOS; In tetrahydrofuran; at -78 ℃; for 5h;

DOI:10.1002/ejoc.201201589

Reference yield: 63.0%

(SS,RC)-diethyl [4-phenyl-2-(p-tolylsulfinylamino)buten-3-yl]phosphonate (180906-45-0) → [(R)-2-amino-4-phenylbuten-3-yl]phosphonic acid

Guidance literature:

With hydrogenchloride; water; for 5h; Reflux;

DOI:10.1002/ejoc.201201589

Reference yield:

(SS,RC)-diethyl [4-phenyl-2-(p-tolylsulfinylamino)buten-3-yl]phosphonate (180906-45-0) → C14H22NO5PS

Guidance literature:

With ozone; In methanol; dichloromethane; at -78 ℃; for 0.25h;

DOI:10.1002/ejoc.201201589

upstream raw materials:

Diethyl methylphosphonate

C₁₆H₁₅NOS

Downstream raw materials:

(S_S,R_C)-diethyl [3-mesyloxy-2-(p-tolylsulfinylamino)propane]phosphonate

(S_S,R_C)-diethyl 3-dimethylamino-2-[(p-tolylsulfinylamino)propane]-phosphonate

(S_S,R_C)-[3-(dimethoxyphosphoryl)-2-(p-tolylsulfinylamino)propyl]-trimethylammonium iodide

(S_S,R_C)-diethyl [3-hydroxy-2-(p-tolylsulfinylamino)propane]phosphonate