(S)-tert-butyl 4'-((5-((1-(4-(tert-butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 4'-((5-((1-(4-(tert-butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
CAS No.:1415256-24-4
Molecular Formula:C₄₁H₄₆N₂O₃
Molecular Weight:614.828
Hs Code.:

Synonyms:(S)-tert-butyl 4'-((5-((1-(4-(tert-butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylate

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Chemical Property of (S)-tert-butyl 4'-((5-((1-(4-(tert-butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylate

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Technology Process of (S)-tert-butyl 4'-((5-((1-(4-(tert-butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylate

There total 14 articles about (S)-tert-butyl 4'-((5-((1-(4-(tert-butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415256-20-0
1-((2'-(tert-butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid

: 1415303-39-7,91552-71-5
(S)-1-(4-(tert-butyl)phenyl)ethan-1-amine hydrochloride

: 1415256-24-4
(S)-tert-butyl 4'-((5-((1-(4-(tert-butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylate

Guidance literature:: 1-((2'-(tert-butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.0833333h;

(S)-1-(4-(tert-butyl)phenyl)ethan-1-amine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 55666-42-7
tert-butyl 2-bromobenzoate

: 1415256-24-4
(S)-tert-butyl 4'-((5-((1-(4-(tert-butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.67 h / 100 °C / Sealed vial

2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 2 h / 100 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

3.2: 1 h / 0 - 20 °C

4.1: sodium hydroxide / ethanol / 2 h / 100 °C

4.2: 20 °C / pH ~ 4

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h

5.2: 0.5 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 88-65-3
2-bromobenzoic-acid

: 1415256-24-4
(S)-tert-butyl 4'-((5-((1-(4-(tert-butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dicyclohexyl-carbodiimide / dmap / dichloromethane / 20 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.67 h / 100 °C / Sealed vial

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 2 h / 100 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

4.2: 1 h / 0 - 20 °C

5.1: sodium hydroxide / ethanol / 2 h / 100 °C

5.2: 20 °C / pH ~ 4

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h

6.2: 0.5 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; HATU; sodium hydroxide; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;