N-(2-(2-hydroxyethoxy)ethyl)-N'-(4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)isophthalamide

Base Information

Chemical Name:N-(2-(2-hydroxyethoxy)ethyl)-N'-(4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)isophthalamide
CAS No.:1354721-69-9
Molecular Formula:C₃₄H₃₅F₃N₆O₅
Molecular Weight:664.684
Hs Code.:

Synonyms:N-(2-(2-hydroxyethoxy)ethyl)-N'-(4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)isophthalamide

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Chemical Property of N-(2-(2-hydroxyethoxy)ethyl)-N'-(4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)isophthalamide

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Technology Process of N-(2-(2-hydroxyethoxy)ethyl)-N'-(4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)isophthalamide

There total 7 articles about N-(2-(2-hydroxyethoxy)ethyl)-N'-(4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1354652-87-1
3-((2-(2-hydroxyethoxy)ethyl)carbamoyl)benzoic acid

: 1354722-24-9
2-amino-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)benzamide

: 1354721-69-9
N-(2-(2-hydroxyethoxy)ethyl)-N'-(4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)isophthalamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃;

Reference yield:

: 401-81-0
m-trifluoromethylphenyl iodide

: 1354721-69-9
N-(2-(2-hydroxyethoxy)ethyl)-N'-(4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)isophthalamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 85 °C

2: hydrogen / palladium on activated charcoal / methanol / 4 h / 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 28 °C

4: hydrogen / palladium on activated charcoal / dichloromethane; methanol / 20 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 25 °C

With dmap; copper(l) iodide; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; L-proline; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1353855-21-6
1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-amine

: 1354721-69-9
N-(2-(2-hydroxyethoxy)ethyl)-N'-(4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)isophthalamide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 28 °C

2: hydrogen / palladium on activated charcoal / dichloromethane; methanol / 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 25 °C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane;