4-Methoxy-N-{2-oxo-6-phenyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-benzamide

Base Information

Chemical Name:4-Methoxy-N-{2-oxo-6-phenyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-benzamide
CAS No.:147283-43-0
Molecular Formula:C₂₇H₂₈F₃N₃O₅
Molecular Weight:531.532
Hs Code.:

Synonyms:4-Methoxy-N-{2-oxo-6-phenyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-benzamide

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Chemical Property of 4-Methoxy-N-{2-oxo-6-phenyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-benzamide

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Technology Process of 4-Methoxy-N-{2-oxo-6-phenyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-benzamide

There total 4 articles about 4-Methoxy-N-{2-oxo-6-phenyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147269-02-1
2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

: 147283-43-0
4-Methoxy-N-{2-oxo-6-phenyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 5 h / 760 Torr

2: Et₃N / tetrahydrofuran

3: tetrabutylammonium fluoride / tetrahydrofuran / 4.5 h

With tetrabutyl ammonium fluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jm00046a016

Reference yield:

: 147313-47-1
N-(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-6-phenyl-1,2-dihydro-pyridin-3-yl)-4-methoxy-benzamide

: 147283-43-0
4-Methoxy-N-{2-oxo-6-phenyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-benzamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 4.5h;
DOI:10.1021/jm00046a016

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 147283-43-0
4-Methoxy-N-{2-oxo-6-phenyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran

2: tetrabutylammonium fluoride / tetrahydrofuran / 4.5 h

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm00046a016