1-(3',6'-anhydro-5'-O-benzyl-2'-O-methylthiocarbonyloxy-β-D-glucofuranosyl)-thymine

Base Information

Chemical Name:1-(3',6'-anhydro-5'-O-benzyl-2'-O-methylthiocarbonyloxy-β-D-glucofuranosyl)-thymine
CAS No.:475558-31-7
Molecular Formula:C₂₀H₂₂N₂O₆S₂
Molecular Weight:450.536
Hs Code.:

Synonyms:1-(3',6'-anhydro-5'-O-benzyl-2'-O-methylthiocarbonyloxy-β-D-glucofuranosyl)-thymine

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Chemical Property of 1-(3',6'-anhydro-5'-O-benzyl-2'-O-methylthiocarbonyloxy-β-D-glucofuranosyl)-thymine

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Technology Process of 1-(3',6'-anhydro-5'-O-benzyl-2'-O-methylthiocarbonyloxy-β-D-glucofuranosyl)-thymine

There total 3 articles about 1-(3',6'-anhydro-5'-O-benzyl-2'-O-methylthiocarbonyloxy-β-D-glucofuranosyl)-thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 75-15-0,12122-00-8
carbon disulfide

: 475558-30-6
1-(3',6'-anhydro-5'-O-benzyl-β-D-glucofuranosyl)-thymine

: 74-88-4
methyl iodide

: 475558-31-7
1-(3',6'-anhydro-5'-O-benzyl-2'-O-methylthiocarbonyloxy-β-D-glucofuranosyl)-thymine

Guidance literature:: carbon disulfide; 1-(3',6'-anhydro-5'-O-benzyl-β-D-glucofuranosyl)-thymine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1081/SCC-120003393

Reference yield:

: 7288-28-0
2,4-bis(trimethylsiloxy)-5-methylpyrimidine

: 475558-31-7
1-(3',6'-anhydro-5'-O-benzyl-2'-O-methylthiocarbonyloxy-β-D-glucofuranosyl)-thymine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 69.5 percent / SnCl₄ / CH₂Cl₂ / 16 h / 20 °C

2.1: 86 percent / NaOMe / methanol / 2 h / 20 °C

3.1: NaH / tetrahydrofuran / 0.25 h / 0 °C

3.2: 91 percent / tetrahydrofuran / 0 - 20 °C

With sodium methylate; tin(IV) chloride; sodium hydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1081/SCC-120003393

Reference yield:

: 475558-28-2
1-(2'-O-acetyl-3',6'-anhydro-5'-O-benzyl-β-D-glucofuranosyl)-thymine

: 475558-31-7
1-(3',6'-anhydro-5'-O-benzyl-2'-O-methylthiocarbonyloxy-β-D-glucofuranosyl)-thymine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / NaOMe / methanol / 2 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.25 h / 0 °C

2.2: 91 percent / tetrahydrofuran / 0 - 20 °C

With sodium methylate; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1081/SCC-120003393