(3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-3,5-diphenyl-1-(p-tolyl)pent-1-yn-3-yl acetate

Base Information

Chemical Name:(3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-3,5-diphenyl-1-(p-tolyl)pent-1-yn-3-yl acetate
CAS No.:1427519-85-4
Molecular Formula:C₃₆H₃₅NO₄S
Molecular Weight:577.744
Hs Code.:

Synonyms:(3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-3,5-diphenyl-1-(p-tolyl)pent-1-yn-3-yl acetate

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Chemical Property of (3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-3,5-diphenyl-1-(p-tolyl)pent-1-yn-3-yl acetate

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Technology Process of (3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-3,5-diphenyl-1-(p-tolyl)pent-1-yn-3-yl acetate

There total 2 articles about (3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-3,5-diphenyl-1-(p-tolyl)pent-1-yn-3-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₁NO₄S

: 106-95-6
allyl bromide

: 1427519-85-4
(3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-3,5-diphenyl-1-(p-tolyl)pent-1-yn-3-yl acetate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jo400121j

Reference yield:

: 1383950-40-0
N-((2S,3S)-3-hydroxy-1,3-diphenyl-5-(p-tolyl)pent-4-yn-2-yl)-4-methylbenzenesulfonamide

: 1427519-85-4
(3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-3,5-diphenyl-1-(p-tolyl)pent-1-yn-3-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

1.2: 0.5 h / 0 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo400121j

Reference yield: 93.0%

: 1427519-85-4
(3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-3,5-diphenyl-1-(p-tolyl)pent-1-yn-3-yl acetate

: 1427520-23-7
((3R,6S)-6-benzyl-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(p-tolyl)methanone

: 64-19-7,77671-22-8
acetic acid

Guidance literature:: With Echavarren's catalyst; water; In 1,2-dichloro-ethane; at 80 ℃; for 24h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jo400121j