(3'S,4'R)-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide

Base Information

Chemical Name:(3'S,4'R)-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide
CAS No.:949152-09-4
Molecular Formula:C₃₅H₄₁Cl₃N₄O₄
Molecular Weight:688.094
Hs Code.:

(3'S,4'R)-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide

Synonyms:(3'S,4'R)-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide

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Chemical Property of (3'S,4'R)-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide

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Technology Process of (3'S,4'R)-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide

There total 3 articles about (3'S,4'R)-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide

: 949152-09-4
(3'S,4'R)-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide

Guidance literature:: Resolution of racemate;

Reference yield:

: (3'S,4'R)-3'-{[2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylcarbamoyl}-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester

: (3'R,4'S)-3'-{[2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylcarbamoyl}-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester

: 949152-09-4
(3'S,4'R)-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide

: 949152-23-2
(3'R,4'S)-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide

Guidance literature:: (3'S,4'R)-3'-{[2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylcarbamoyl}-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester; (3'R,4'S)-3'-{[2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylcarbamoyl}-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 1h;

With sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane; water; ethyl acetate;