(1S,2'S,2S)-2,4-dimethyl-2-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-1-benzyl(oxy)-3-cyclohexene

Base Information

Chemical Name:(1S,2'S,2S)-2,4-dimethyl-2-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-1-benzyl(oxy)-3-cyclohexene
CAS No.:188052-28-0
Molecular Formula:C₂₂H₃₁NO₃
Molecular Weight:357.493
Hs Code.:

Synonyms:(1S,2'S,2S)-2,4-dimethyl-2-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-1-benzyl(oxy)-3-cyclohexene

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Chemical Property of (1S,2'S,2S)-2,4-dimethyl-2-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-1-benzyl(oxy)-3-cyclohexene

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Technology Process of (1S,2'S,2S)-2,4-dimethyl-2-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-1-benzyl(oxy)-3-cyclohexene

There total 5 articles about (1S,2'S,2S)-2,4-dimethyl-2-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-1-benzyl(oxy)-3-cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 100-39-0
benzyl bromide

: 237406-11-0
(1S,2'S,2S)-2,4-dimethyl-2-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-3-cyclohexen-1-ol

: 188052-28-0
(1S,2'S,2S)-2,4-dimethyl-2-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-1-benzyl(oxy)-3-cyclohexene

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium hydride; In tetrahydrofuran; 1.) room temp., 24 h, 2.) reflux, 3 d;
DOI:10.1016/S0040-4020(99)00305-1

Reference yield:

: 115512-81-7
(S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-methylbenzene

: 188052-28-0
(1S,2'S,2S)-2,4-dimethyl-2-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-1-benzyl(oxy)-3-cyclohexene

Guidance literature:: Multi-step reaction with 5 steps

1: K, NH₃ / tetrahydrofuran; 2-methyl-propan-2-ol / 0.5 h / -78 °C

2: n-BuLi, HMPA / tetrahydrofuran; hexane / 1.5 h / -78 °C

3: 91 percent / aq. HCl / tetrahydrofuran / 2 h / Ambient temperature

4: 100 percent / NaBH₄, ZnCl₂ / tetrahydrofuran / 1 h / -60 - -15 °C

5: 63 percent / KH, n-Bu₄NI / tetrahydrofuran / 1.) room temp., 24 h, 2.) reflux, 3 d

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; n-butyllithium; ammonia; tetra-(n-butyl)ammonium iodide; potassium hydride; zinc(II) chloride; In tetrahydrofuran; hexane; tert-butyl alcohol;
DOI:10.1016/S0040-4020(99)00305-1

Reference yield:

: 115513-10-5
((S)-2-Methoxy-1,5-dimethyl-cyclohexa-2,5-dienyl)-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone

: 188052-28-0
(1S,2'S,2S)-2,4-dimethyl-2-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-1-benzyl(oxy)-3-cyclohexene

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / aq. HCl / tetrahydrofuran / 2 h / Ambient temperature

2: 100 percent / NaBH₄, ZnCl₂ / tetrahydrofuran / 1 h / -60 - -15 °C

3: 63 percent / KH, n-Bu₄NI / tetrahydrofuran / 1.) room temp., 24 h, 2.) reflux, 3 d

With hydrogenchloride; sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; potassium hydride; zinc(II) chloride; In tetrahydrofuran;
DOI:10.1016/S0040-4020(99)00305-1