ethyl (2R,3R)-3-methyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate

Base Information

• Chemical Name: ethyl (2R,3R)-3-methyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate
• CAS No.: 884318-73-4
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.31
• Mol file: 884318-73-4.mol

Synonyms:ethyl (2R,3R)-3-methyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate

Chemical Property of ethyl (2R,3R)-3-methyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2R,3R)-3-methyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate

There total 12 articles about ethyl (2R,3R)-3-methyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(2S,3R)-ethyl 3-(N-((R)-1-phenylethyl)amino)-2-(phenylselanyl)butanoate (884318-83-6) → ethyl (2R,3R)-3-methyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate (884318-73-4)

Guidance literature:

(2S,3R)-ethyl 3-(N-((R)-1-phenylethyl)amino)-2-(phenylselanyl)butanoate; With trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 12h;

With sodium hydroxide; In dichloromethane;

DOI:10.1016/j.tet.2005.12.030

Reference yield: 47.0%

(2S,3S)-ethyl 2-((R)-1-phenylethylamino)-3-(phenylselanyl)butanoate (884318-66-5) → ethyl (2R,3R)-3-methyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate (884318-73-4)

Guidance literature:

(2S,3S)-ethyl 2-((R)-1-phenylethylamino)-3-(phenylselanyl)butanoate; With trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 12h;

With sodium hydroxide; In dichloromethane;

DOI:10.1016/j.tet.2005.12.030

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + 2-((R)-1-Phenyl-ethylamino)-propionitrile (389631-33-8) → ethyl (2S,3S)-3-methyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate + ethyl (2R,3R)-3-methyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate (884318-73-4)

Guidance literature:

With tin(IV) chloride; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1016/S0040-4020(01)00823-7

upstream raw materials:

diazoacetic acid ethyl ester

2-((R)-1-Phenyl-ethylamino)-propionitrile

(2S,3S)-ethyl 2-((R)-1-phenylethylamino)-3-(phenylselanyl)butanoate

(2S,3R)-ethyl 3-(N-((R)-1-phenylethyl)amino)-2-(phenylselanyl)butanoate

Downstream raw materials:

ethyl (2R,3R)-3-acetyloxy-2-[(R)-1-phenylethylamino]butanoate