1-(3-tert-butyl-5-formyl-4-methoxybenzyl)-1,3-dimethyl-3-phenylurea

Base Information

• Chemical Name: 1-(3-tert-butyl-5-formyl-4-methoxybenzyl)-1,3-dimethyl-3-phenylurea
• CAS No.: 1279725-27-7
• Molecular Formula: C₂₂H₂₈N₂O₃
• Molecular Weight: 368.476
• Mol file: 1279725-27-7.mol

Synonyms:1-(3-tert-butyl-5-formyl-4-methoxybenzyl)-1,3-dimethyl-3-phenylurea

Chemical Property of 1-(3-tert-butyl-5-formyl-4-methoxybenzyl)-1,3-dimethyl-3-phenylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-tert-butyl-5-formyl-4-methoxybenzyl)-1,3-dimethyl-3-phenylurea

There total 1 articles about 1-(3-tert-butyl-5-formyl-4-methoxybenzyl)-1,3-dimethyl-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-(3-tert-butyl-5-formyl-4-hydroxybenzyl)-3-phenylurea (1279725-33-5) + methyl iodide (74-88-4) → 1-(3-tert-butyl-5-formyl-4-methoxybenzyl)-1,3-dimethyl-3-phenylurea (1279725-27-7)

Guidance literature:

1-(3-tert-butyl-5-formyl-4-hydroxybenzyl)-3-phenylurea; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201002600

Reference yield: 80.0%

1-(3-tert-butyl-5-formyl-4-methoxybenzyl)-1,3-dimethyl-3-phenylurea (1279725-27-7) → 1-(3-tert-butyl-5-formyl-4-hydroxybenzyl)-1,3-dimethyl-3-phenylurea (1279725-28-8)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1002/chem.201002600

Reference yield:

1-(3-tert-butyl-5-formyl-4-methoxybenzyl)-1,3-dimethyl-3-phenylurea (1279725-27-7) → 1,1'-(5,5'-(1E,1'E)-(1R,2R)-cyclohexane-1,2-diylbis(azan-1-yl-1-ylidene)bis(methan-1-yl-1-ylidene)bis(3-tert-butyl-4-hydroxy-5,1-phenylene)bis(methylene))bis(1,3-dimethyl-3-phenylurea) (1279725-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 1 h / -78 °C

2: tetrahydrofuran / 20 h / 20 °C

With boron tribromide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.201002600

upstream raw materials:

1-(3-tert-butyl-5-formyl-4-hydroxybenzyl)-3-phenylurea

methyl iodide

Downstream raw materials:

1-(3-tert-butyl-5-formyl-4-hydroxybenzyl)-1,3-dimethyl-3-phenylurea

1,1'-(5,5'-(1E,1'E)-(1R,2R)-cyclohexane-1,2-diylbis(azan-1-yl-1-ylidene)bis(methan-1-yl-1-ylidene)bis(3-tert-butyl-4-hydroxy-5,1-phenylene)bis(methylene))bis(1,3-dimethyl-3-phenylurea)