Technology Process of N-(5-ethyl-1H-pyrazol-3-yl)-2-(4-hydroxy-2-methoxyphenyl)acetamide
There total 6 articles about N-(5-ethyl-1H-pyrazol-3-yl)-2-(4-hydroxy-2-methoxyphenyl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: methanol; sodium hydroxide; water / tetrahydrofuran / 24 h / 85 °C
1.2: pH 2
2.1: 2-hydroxy-pyridine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 - 70 °C
3.1: ammonium formate / palladium 10% on activated carbon / N,N-dimethyl-formamide / 1.5 h / 70 °C
With
methanol; sodium hydroxide; 2-hydroxy-pyridine N-oxide; water; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / methanol; 1,2-dimethoxyethane / 3 h / -78 °C / Heating / reflux
2.1: methanol; sodium hydroxide; water / tetrahydrofuran / 24 h / 85 °C
2.2: pH 2
3.1: 2-hydroxy-pyridine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 - 70 °C
4.1: ammonium formate / palladium 10% on activated carbon / N,N-dimethyl-formamide / 1.5 h / 70 °C
With
methanol; sodium hydroxide; 2-hydroxy-pyridine N-oxide; potassium tert-butylate; water; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl acetamide / 2 h / 50 °C
2.1: potassium tert-butylate / methanol; 1,2-dimethoxyethane / 3 h / -78 °C / Heating / reflux
3.1: methanol; sodium hydroxide; water / tetrahydrofuran / 24 h / 85 °C
3.2: pH 2
4.1: 2-hydroxy-pyridine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 - 70 °C
5.1: ammonium formate / palladium 10% on activated carbon / N,N-dimethyl-formamide / 1.5 h / 70 °C
With
methanol; sodium hydroxide; 2-hydroxy-pyridine N-oxide; potassium tert-butylate; water; ammonium formate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
