(S)-2-(2-methylphenyl)-2-trimethylsilyloxyacetonitrile

Base Information

• Chemical Name: (S)-2-(2-methylphenyl)-2-trimethylsilyloxyacetonitrile
• CAS No.: 191792-45-7
• Molecular Formula: C₁₂H₁₇NOSi
• Molecular Weight: 219.359
• Mol file: 191792-45-7.mol

Synonyms:(S)-2-(2-methylphenyl)-2-trimethylsilyloxyacetonitrile

Chemical Property of (S)-2-(2-methylphenyl)-2-trimethylsilyloxyacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2-methylphenyl)-2-trimethylsilyloxyacetonitrile

There total 2 articles about (S)-2-(2-methylphenyl)-2-trimethylsilyloxyacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethylsilyl cyanide (7677-24-9) + 2-methylphenyl aldehyde (529-20-4) → (R)-2-(2-methylphenyl)-2-trimethylsilyloxyacetonitrile (114579-90-7) + (S)-2-(2-methylphenyl)-2-trimethylsilyloxyacetonitrile (191792-45-7)

Guidance literature:

With chiral salenTi(OPr-i)4; In dichloromethane; Yield given. Yields of byproduct given. Title compound not separated from byproducts; 1.) r.t., 1 h, 2.) -80 deg C;

Reference yield:

trimethylsilyl cyanide (7677-24-9) + 2-methylphenyl aldehyde (529-20-4) → (S)-2-(2-methylphenyl)-2-trimethylsilyloxyacetonitrile (191792-45-7)

Guidance literature:

With titanium(IV) isopropylate; (1R)-(+)-α-pinene dirived bipyridyldiol; In dichloromethane; at -78 ℃; for 40h;

DOI:10.1016/j.tetasy.2005.05.035

Reference yield:

acetic anhydride (108-24-7) + (S)-2-(2-methylphenyl)-2-trimethylsilyloxyacetonitrile (191792-45-7) → (S)-O-acetyl-2-hydroxy-2-(2-methylphenyl)acetonitrile

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In acetonitrile; at 20 ℃; for 0.333333h;

DOI:10.1016/j.tetasy.2008.11.037

upstream raw materials:

trimethylsilyl cyanide

2-methylphenyl aldehyde

Downstream raw materials:

(S)-(-)-α-hydroxy-2-methylphenylacetonitrile