2-[2-chloro-5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)phenoxy]acetamide

Base Information

Chemical Name:2-[2-chloro-5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)phenoxy]acetamide
CAS No.:1443151-73-2
Molecular Formula:C₂₀H₁₉ClFN₅O₃
Molecular Weight:431.854
Hs Code.:

Synonyms:2-[2-chloro-5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)phenoxy]acetamide

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Chemical Property of 2-[2-chloro-5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)phenoxy]acetamide

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Technology Process of 2-[2-chloro-5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)phenoxy]acetamide

There total 7 articles about 2-[2-chloro-5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)phenoxy]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443151-96-9
[2-chloro-5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)phenoxy]acetic acid

: 1443151-73-2
2-[2-chloro-5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)phenoxy]acetamide

Guidance literature:: With ammonium hydroxide; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 183802-98-4
5-bromo-2-chlorophenol

: 1443151-73-2
2-[2-chloro-5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)phenoxy]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,2-dimethoxyethane / 3.5 h / Reflux

3: potassium carbonate / acetone / 5 h / 20 °C

4: lithium hydroxide monohydrate / tetrahydrofuran / 0.5 h

5: ammonium hydroxide; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 24 h / 20 °C

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; potassium acetate; potassium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1443151-85-6
2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1443151-73-2
2-[2-chloro-5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)phenoxy]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,2-dimethoxyethane / 3.5 h / Reflux

2: potassium carbonate / acetone / 5 h / 20 °C

3: lithium hydroxide monohydrate / tetrahydrofuran / 0.5 h

4: ammonium hydroxide; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 24 h / 20 °C

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; potassium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetone;