2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Base Information

Chemical Name:2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
CAS No.:1443151-85-6
Molecular Formula:C₁₂H₁₆BClO₃
Molecular Weight:254.521
Hs Code.:
Mol file:1443151-85-6.mol

Synonyms:2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Suppliers and Price of 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 95+%
1g
$ 465.00

AOBChem
4-Chloro-3-hydroxyphenylboronicacidpinacolester 97%
1g
$ 230.00

AOBChem
4-Chloro-3-hydroxyphenylboronic acid pinacol ester 97%
500mg
$ 164.00

AOBChem
4-Chloro-3-hydroxyphenylboronic acid pinacol ester 97%
50g
$ 4760.00

AOBChem
4-Chloro-3-hydroxyphenylboronic acid pinacol ester 97%
25g
$ 2750.00

AOBChem
4-Chloro-3-hydroxyphenylboronic acid pinacol ester 97%
10g
$ 1400.00

AOBChem
4-Chloro-3-hydroxyphenylboronic acid pinacol ester 97%
5g
$ 823.00

Total 2 raw suppliers

Chemical Property of 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Chemical Property:

Boiling Point:350.5±32.0 °C(Predicted)
PKA:8.54±0.10(Predicted)
Density:1.19±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

There total 4 articles about 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 183802-98-4
5-bromo-2-chlorophenol

: 73183-34-3
bis(pinacol)diborane

: 1443151-85-6
2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; In N,N-dimethyl-formamide; for 2h; Reflux;

Reference yield:

: 214360-76-6
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1151564-17-8
2-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1443151-85-6
2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Guidance literature:: With 1,3-dichloro-5,5-dimethylhydantoin; diisopropylamine hydrochloride; In toluene; at 0 ℃; for 4h; Overall yield = 64 %; regioselective reaction; Darkness;
DOI:10.1021/acscatal.8b00327

Reference yield:

: tetrabutylammonium 2‐chlorophenyl sulfate

: 73183-34-3
bis(pinacol)diborane

: 629658-06-6
2‐chloro‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenol

: 1443151-85-6
2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Guidance literature:: tetrabutylammonium 2‐chlorophenyl sulfate; bis(pinacol)diborane; With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-Dimethoxy-2,2'-bipyridin; In 1,4-dioxane; at 40 ℃; for 14h; Glovebox;

With hydrogenchloride; In 1,4-dioxane; water; for 1h; pH=1 - 2; regioselective reaction; Glovebox;
DOI:10.1021/jacs.9b08464