cis-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetic acid

Base Information

Chemical Name:cis-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetic acid
CAS No.:1239310-61-2
Molecular Formula:C₂₄H₂₅N₃O₃S
Molecular Weight:435.547
Hs Code.:

Synonyms:cis-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetic acid

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Chemical Property of cis-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetic acid

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Technology Process of cis-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetic acid

There total 7 articles about cis-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239310-64-5
tert-butyl trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetate

: 1239310-63-4
trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyl}acetic acid

: 1239310-61-2
cis-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 433211-87-1
4-[4-(ethoxycarbonyl)phenyl]cyclohexanone

: 1239310-63-4
trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyl}acetic acid

: 1239310-61-2
cis-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 4 °C

1.2: 4 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 25 °C / 2585.81 Torr

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 4 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1237147-82-8
ethyl 4-(4-tert-butoxycarbonylmethylenecyclohexyl)benzoate

: 1239310-63-4
trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyl}acetic acid

: 1239310-61-2
cis-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 25 °C / 2585.81 Torr

2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;