tert-butyl trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetate

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Chemical Name:tert-butyl trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetate
CAS No.:1239310-64-5
Molecular Formula:C₂₈H₃₃N₃O₃S
Molecular Weight:491.654
Hs Code.:

Synonyms:tert-butyl trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetate

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Chemical Property of tert-butyl trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetate

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Technology Process of tert-butyl trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetate

There total 4 articles about tert-butyl trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1237147-83-9
ethyl 4-(4-tert-butoxycarbonylmethylcyclohexyl)benzoate

: 1239310-64-5
tert-butyl trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 433211-87-1
4-[4-(ethoxycarbonyl)phenyl]cyclohexanone

: 1239310-64-5
tert-butyl trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 4 °C

1.2: 4 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 25 °C / 2585.81 Torr

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 4 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1237147-82-8
ethyl 4-(4-tert-butoxycarbonylmethylenecyclohexyl)benzoate

: 1239310-64-5
tert-butyl trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 25 °C / 2585.81 Torr

2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;