5-Amino-2-fluorophenylacetic acid 98%

Base Information

• Chemical Name: 5-Amino-2-fluorophenylacetic acid 98%
• CAS No.: 518057-74-4
• Molecular Formula: C₈H₈FNO₂
• Molecular Weight: 169.155
• Hs Code.: 2922498590
• Mol file: 518057-74-4.mol

Synonyms:(5-amino-2-fluoro-phenyl)-acetic acid

Chemical Property of 5-Amino-2-fluorophenylacetic acid 98%

Chemical Property:

• Boiling Point: 354.0±27.0 °C(Predicted)
• PKA: 3.80±0.10(Predicted)
• Density: 1.371±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98% ^*data from raw suppliers

5-Amino-2-fluorophenylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Amino-2-fluorophenylacetic acid 98%

There total 1 articles about 5-Amino-2-fluorophenylacetic acid 98% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-(2-fluoro-5-nitrophenyl)acetic acid (195609-18-8) → (5-amino-2-fluoro-phenyl)-acetic acid (518057-74-4)

Guidance literature:

With iron; ammonium chloride; In tetrahydrofuran; ethanol; water; at 80 ℃; for 1h;

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (5-amino-2-fluoro-phenyl)-acetic acid (518057-74-4) → methyl 2-(5-amino-2-fluorophenyl)acetate (1338367-30-8)

Guidance literature:

In diethyl ether; ethyl acetate;

DOI:10.1016/j.bmc.2011.08.007

Reference yield: 95.0%

ethanol (64-17-5) + (5-amino-2-fluoro-phenyl)-acetic acid (518057-74-4) → ethyl 2-(5-amino-2-fluorophenyl)acetate (1239460-72-0)

Guidance literature:

With sulfuric acid; at 80 ℃; for 1h; Inert atmosphere;

upstream raw materials:

2-(2-fluoro-5-nitrophenyl)acetic acid

Downstream raw materials:

ethyl 2-(5-amino-2-fluorophenyl)acetate

methyl 2-(5-amino-2-fluorophenyl)acetate

Refernces