tert-butyl 4-[2-(3-nitrophenoxy)ethyl]tetrahydro-1(2H)-pyrazinecarboxylate

Base Information

• Chemical Name: tert-butyl 4-[2-(3-nitrophenoxy)ethyl]tetrahydro-1(2H)-pyrazinecarboxylate
• CAS No.: 1135283-71-4
• Molecular Formula: C₁₇H₂₅N₃O₅
• Molecular Weight: 351.403
• Mol file: 1135283-71-4.mol

Synonyms:tert-butyl 4-(2-(3-nitrophenoxy)ethyl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-[2-(3-nitrophenoxy)ethyl]tetrahydro-1(2H)-pyrazinecarboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-[2-(3-Nitrophenoxy)ethyl]tetrahydro-1(2H)-pyrazinecarboxylate ^*data from reagent suppliers

Safty Information:

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Technology Process of tert-butyl 4-[2-(3-nitrophenoxy)ethyl]tetrahydro-1(2H)-pyrazinecarboxylate

There total 2 articles about tert-butyl 4-[2-(3-nitrophenoxy)ethyl]tetrahydro-1(2H)-pyrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(3-nitrophenoxy)bromoethane (13831-59-9) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(2-(3-nitrophenoxy)ethyl)piperazine-1-carboxylate (1135283-71-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; Reflux; Inert atmosphere;

DOI:10.1021/jm101087u

Reference yield:

meta-nitrophenol (554-84-7) → tert-butyl 4-(2-(3-nitrophenoxy)ethyl)piperazine-1-carboxylate (1135283-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

2: triethylamine / tetrahydrofuran / 60 °C / Inert atmosphere

With potassium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 99.0%

tert-butyl 4-(2-(3-nitrophenoxy)ethyl)piperazine-1-carboxylate (1135283-71-4) → tert-butyl 4-(2-(3-aminophenoxy)ethyl)piperazine-1-carboxylate (1135283-72-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol;

upstream raw materials:

2-(3-nitrophenoxy)bromoethane

1-t-Butoxycarbonylpiperazine

meta-nitrophenol

Downstream raw materials:

tert-butyl 4-(2-(3-aminophenoxy)ethyl)piperazine-1-carboxylate

1-adamantan-1-yl-3-(3-(2-(piperazin-1-yl)ethoxy)phenyl)urea

tert-butyl 4-(2-(3-(3-(adamantan-1-yl)ureido)phenoxy)ethyl)piperazine-1-carboxylate

1-adamantan-1-yl-3-(3-(2-(4-acetylpiperazin-1-yl)ethoxy)phenyl)urea

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