13831-59-9

Usage

Chemical Properties

Yellowish-green or brown low melting solid

InChI:InChI=1/C8H8BrNO3/c9-4-5-13-8-3-1-2-7(6-8)10(11)12/h1-3,6H,4-5H2

Upstream product

• 554-84-7 meta-nitrophenol 
• 106-93-4 ethylene dibromide 
• 3019-85-0 sodium 3-nitrophenoxide 
• 540-51-2 2-bromoethanol 

Downstream Products

• 31185-40-7 4-[2-(3-Nitro-phenoxy)-ethoxy]-benzenesulfonyl fluoride 
• 91761-27-2 N,N-dimethyl-2-(3-nitrophenoxy)ethan-1-amine 
• 19160-69-1 N-<2-(3-Nitrophenyloxy)-ethyl>-cyclopropylamin 
• 19157-66-5 N-{3-[2-(3-Nitro-phenoxy)-ethoxy]-phenyl}-acetamide 
• 213606-47-4 N,N-diethyl-1-(3-nitrophenoxy)aminoethane 
• 125174-59-6 C₁₇H₂₃N₃O 
• 115256-30-9 N-[3-(2-{[2-(4-Methanesulfonylamino-phenyl)-ethyl]-methyl-amino}-ethoxy)-phenyl]-methanesulfonamide 
• 98147-13-8 Benzyl-dimethyl-[2-(3-nitro-phenoxy)-ethyl]-ammonium; chloride 
• 98654-47-8 (2-Chloro-benzyl)-dimethyl-[2-(3-nitro-phenoxy)-ethyl]-ammonium; chloride 
• 98654-48-9 (4-Chloro-benzyl)-dimethyl-[2-(3-nitro-phenoxy)-ethyl]-ammonium; chloride 
• 98692-86-5 (3-Chloro-benzyl)-dimethyl-[2-(3-nitro-phenoxy)-ethyl]-ammonium; bromide 
• 98654-42-3 Dimethyl-(4-nitro-benzyl)-[2-(3-nitro-phenoxy)-ethyl]-ammonium; chloride 
• 1227004-52-5 C₂₆H₂₂N₂O₈ 
• 1093799-22-4 C₂₀H₃₂N₂O₆ 

Relevant academic research and scientific papers

Diphenoxyl flexible molecules with high affinity with A[beta] plaque and preparation method and applications thereof

The invention discloses diphenoxyl flexible molecules with high affinity with A[beta] plaque and a preparation method and applications thereof. After the molecules are labeled by radionuclide, the molecules can be used as an A[beta] plaque developing agen

Synthesis and Investigation of S-Substituted 2-Mercaptobenzoimidazoles as Inhibitors of Hedgehog Signaling

Due to the arising resistance of common drugs targeting the Hedgehog signaling pathway, the identification of new compound classes with inhibitory effect is urgently needed. We were able to identify S-alkylated 2-mercaptobenzoimidazoles as a new compound

Piperazine substituted 1, 3 - di-substituted urea compound and piperazine substituted amide compounds and a method for its preparation and use

The present invention relates to a class of piperazine substituted 1,3-disubstitued urea compounds and piperazine substituted amide compounds, or pharmaceutically acceptable salts of the piperazine substituted 1,3-disubstitued urea compounds and the piper

Induction of molecular chirality by circularly polarized light in cyclic azobenzene with a photoswitchable benzene rotor

New phototriggered molecular machines based on cyclic azobenzene were synthesized in which a 2,5-dimethoxy, 2,5-dimethyl, 2,5-difluorine or unsubstituted-1,4-dioxybenzene rotating unit and a photoisomerizable 3,3′-dioxyazobenzene moiety are bridged together by fixed bismethylene spacers. Depending upon substitution on the benzene moiety and on the E/Z conformation of the azobenzene unit, these molecules suffer various degrees of restriction on the free rotation of the benzene rotor. The rotation of the substituted benzene rotor within the cyclic azobenzene cavity imparts planar chirality to the molecules. Cyclic azobenzene 1, with methoxy groups at both the 2- and 5-positions of the benzene rotor, was so conformationally restricted that free rotation of the rotor was prevented in both the E and Z isomers and the respective planar chiral enantiomers were resolved. In contrast, compound 2, with 2,5-dimethylbenzene as the rotor, demonstrated the property of a light-controlled molecular brake, whereby rotation of the 2,5-dimethylbenzene moiety is completely stopped in the E isomer (brake ON, rotation OFF), while the rotation is allowed in the Z isomer (brake OFF, rotation ON). The cyclic azobenzene 3, with fluorine substitution on the benzene rotor, was in the brake OFF state regardless of E/Z photoisomerization of the azobenzene moiety. More interestingly, for the first time, we demonstrated the induction of molecular chirality in a simple monocyclic azobenzene by circular-polarized light. The key characteristics of cyclic azobenzene 2, that is, stability of the chiral structure in the E isomer, fast racemization in the Z isomer, and the circular dichroism of enantiomers of both E and Z isomers, resulted in a simple reversible enantio-differentiating photoisomerization directly between the E enantiomers. Upon exposure to r- or l-circularly polarized light at 488 nm, partial enrichment of the (S)- or (R)-enantiomers of 2 was observed. Copyright

IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION

Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula (I).

Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties

The inhibition of the mammalian soluble epoxide hydrolase (sEH) is a promising new therapy in the treatment of hypertension, inflammation, and other disorders. However, the problems of limited water solubility, high melting point, and low metabolic stabil

A light-controlled molecular brake with complete ON-OFF rotation

A light-controlled molecular machine based on cyclic azobenzenophanes consisting of a dioxynaphthalene rotating unit and a photoisomerizable dioxyazobenzene unit bridged by methylene spacers is reported. In compounds 1 and 2, 1,5- and 2,6-dioxynaphthalene moieties, respectively, are linked to p-dioxyazobenzene by different methylene spacers (n = 2 in 1a and 2; n = 3 in 1b), whereas a 1,5-dioxynaphthalene moiety is bonded to m-dioxyazobenzene by bismethylene spacers in 3. In 1b and 2, the naphthalene ring can rotate freely in both the trans and cis states at room temperature. The rotation speed can be controlled either by photoinduced reversible trans-cis (E-Z) isomerization of the azobenzene or by keeping the system at low temperature, as is evident from its NMR spectra. Furthermore, for the first time, we demonstrate a light-controlled molecular brake, wherein the rotation of the naphthalene moiety through the cyclophane is completely OFF in the trans isomer of compound 3 due to its smaller cavity size. Such restricted rotation imparts planar chirality to the molecule, and the corresponding enantiomers could be resolved by chiral HPLC. However, the rotation of the naphthalene moiety is rendered ON in the cis isomer due to its increased cavity size, and it is manifested experimentally by the racemization of the separated enantiomers by photoinduced E-Z isomerization.

Synthesis of Quaternary Salts of Ammonia from Phenols and their Plant Growth Retardant Activity

Different phenols, viz. β-naphthol, p-chlorophenol, p-cresol and m-nitrophenol have been converted into (3-diethylamino-2-hydroxypropyloxy) derivatives (4a-d) through the formation of glycidyl ethers (2a-d and 3a-d). m-Nitrophenol and p-chlorophenol have been converted to 2-aryloxy-N,N-diethylaminoethanes (8e,f) through the formation of bromoethers (7e,f). 1,3-Bis(2-diethylaminoethoxy)benzene (12) has been prepared from resorcinol. The tertiary amines (4a-d, 8e,f and 12) are then quaternized with citronellyl bromide and tested as plant growth retardants.

PHOTOINDUCED INTRAMOLECULAR SUBSTITUTION-III PHOTOCYCLIZATION OF ω-ANILINOALKYL m-NITROPHENYL ETHERS

Irradiation of 1-(m-nitrophenoxy)-ω-anilinoalkanes, m-O2NC6H4O(CH2)nNHPh (n = 2 and 3) and their 1-(2-methoxy-5-nitrophenoxy) analogs induced intramolecular cyclization in which a hydrogen or methoxyl