1-(benzyloxy)-2,5-dioxo-3-methylene-4-methyl-6-<(N-methylindol-3-yl)methyl>piperazine

Base Information

Chemical Name:1-(benzyloxy)-2,5-dioxo-3-methylene-4-methyl-6-<(N-methylindol-3-yl)methyl>piperazine
CAS No.:81120-62-9
Molecular Formula:C₂₃H₂₃N₃O₃
Molecular Weight:389.454
Hs Code.:

Synonyms:1-(benzyloxy)-2,5-dioxo-3-methylene-4-methyl-6-<(N-methylindol-3-yl)methyl>piperazine

Suppliers and Price of 1-(benzyloxy)-2,5-dioxo-3-methylene-4-methyl-6-<(N-methylindol-3-yl)methyl>piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(benzyloxy)-2,5-dioxo-3-methylene-4-methyl-6-<(N-methylindol-3-yl)methyl>piperazine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(benzyloxy)-2,5-dioxo-3-methylene-4-methyl-6-<(N-methylindol-3-yl)methyl>piperazine

There total 15 articles about 1-(benzyloxy)-2,5-dioxo-3-methylene-4-methyl-6-<(N-methylindol-3-yl)methyl>piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 100-39-0
benzyl bromide

: 81095-95-6
1-hydroxy-2,5-dioxo-3-methylene-4-methyl-6-<(N-methylindol-3-yl)methyl> piperazine

: 81120-62-9
1-(benzyloxy)-2,5-dioxo-3-methylene-4-methyl-6-<(N-methylindol-3-yl)methyl>piperazine

Guidance literature:: With potassium tert-butylate; In 1,2-dimethoxyethane; for 1h; Ambient temperature;

Reference yield:

: 603-76-9
1-methylindole

: 81120-62-9
1-(benzyloxy)-2,5-dioxo-3-methylene-4-methyl-6-<(N-methylindol-3-yl)methyl>piperazine

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / Na₂CO₃ / CH₂Cl₂ / 16 h / Ambient temperature

2: 100 percent / 50 percent NaOH / tetrabutylammonium chloride / ethanol; H₂O / 1 h / Ambient temperature

3: 0.538 g / methanol / 0.17 h / 0 °C

4: 49 percent / triethylamine borohydride, 7 N HCl / ethanol / 24 h / Ambient temperature

5: 54 percent / dioxane; H₂O / 16 h / Ambient temperature

6: triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

7: CF₃COOH (trace) / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; triethylamine-borane; sodium carbonate; triethylamine; trifluoroacetic acid; tetrabutyl-ammonium chloride; In 1,4-dioxane; methanol; ethanol; dichloromethane; water;
DOI:10.1021/jo00132a032

Reference yield:

: 81095-89-8
ethyl α-(hydroxyimino)-β-(N-methylindol-3-yl)propanoate

: 81120-62-9
1-(benzyloxy)-2,5-dioxo-3-methylene-4-methyl-6-<(N-methylindol-3-yl)methyl>piperazine

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / 50 percent NaOH / tetrabutylammonium chloride / ethanol; H₂O / 1 h / Ambient temperature

2: 0.538 g / methanol / 0.17 h / 0 °C

3: 49 percent / triethylamine borohydride, 7 N HCl / ethanol / 24 h / Ambient temperature

4: 54 percent / dioxane; H₂O / 16 h / Ambient temperature

5: triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

6: CF₃COOH (trace) / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; triethylamine-borane; triethylamine; trifluoroacetic acid; tetrabutyl-ammonium chloride; In 1,4-dioxane; methanol; ethanol; dichloromethane; water;
DOI:10.1021/jo00132a032