[3aR,4R(1E,3RS),5R,6aS]-4-[4-(3-chlorophenoxy)-3-fluoro-1-buten-1-yl]-5-(tetrahydropyran-2-yloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

Base Information

Chemical Name:[3aR,4R(1E,3RS),5R,6aS]-4-[4-(3-chlorophenoxy)-3-fluoro-1-buten-1-yl]-5-(tetrahydropyran-2-yloxy)-hexahydro-2H-cyclopenta[b]furan-2-one
CAS No.:733037-26-8
Molecular Formula:C₂₂H₂₆ClFO₅
Molecular Weight:424.897
Hs Code.:

Synonyms:[3aR,4R(1E,3RS),5R,6aS]-4-[4-(3-chlorophenoxy)-3-fluoro-1-buten-1-yl]-5-(tetrahydropyran-2-yloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

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Chemical Property of [3aR,4R(1E,3RS),5R,6aS]-4-[4-(3-chlorophenoxy)-3-fluoro-1-buten-1-yl]-5-(tetrahydropyran-2-yloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

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Technology Process of [3aR,4R(1E,3RS),5R,6aS]-4-[4-(3-chlorophenoxy)-3-fluoro-1-buten-1-yl]-5-(tetrahydropyran-2-yloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

There total 3 articles about [3aR,4R(1E,3RS),5R,6aS]-4-[4-(3-chlorophenoxy)-3-fluoro-1-buten-1-yl]-5-(tetrahydropyran-2-yloxy)-hexahydro-2H-cyclopenta[b]furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 733037-25-7
[3aR,4R(1E,3RS),5R,6aS]-4-[4-(3-chlorophenoxy)-3-fluoro-1-buten-1-yl]-5-hydroxy-hexahydro-2H-cyclopenta[b]furan-2-one

: 733037-26-8
[3aR,4R(1E,3RS),5R,6aS]-4-[4-(3-chlorophenoxy)-3-fluoro-1-buten-1-yl]-5-(tetrahydropyran-2-yloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1016/j.bmc.2004.04.034

Reference yield:

: 178454-81-4
[3aR,4R(1E),5R,6aS]-5-benzoyloxy-4-[4-(3-chlorophenoxy)-3-oxo-1-buten-1-yl]-hexahydro-2H-cyclopenta[b]furan-2-one

: 733037-26-8
[3aR,4R(1E,3RS),5R,6aS]-4-[4-(3-chlorophenoxy)-3-fluoro-1-buten-1-yl]-5-(tetrahydropyran-2-yloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 49 percent / (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 0 °C

2.1: (diethylamino)sulfur trifluoride / CH₂Cl₂

2.2: 815 mg / K₂CO₃ / methanol

3.1: 96 percent / p-TsOH*H₂O / CH₂Cl₂

With (+)-β-chlorodiisopinocampheylborane; diethylamino-sulfur trifluoride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2004.04.034

Reference yield:

: 208111-89-1
[3aR,4R(1E,3S),5R,6aS]-5-benzoyloxy-4-[4-(3-chlorophenoxy)-3-hydroxy-1-buten-1-yl]-hexahydro-2H-cyclopenta[b]furan-2-one

: 733037-26-8
[3aR,4R(1E,3RS),5R,6aS]-4-[4-(3-chlorophenoxy)-3-fluoro-1-buten-1-yl]-5-(tetrahydropyran-2-yloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: (diethylamino)sulfur trifluoride / CH₂Cl₂

1.2: 815 mg / K₂CO₃ / methanol

2.1: 96 percent / p-TsOH*H₂O / CH₂Cl₂

With diethylamino-sulfur trifluoride; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1016/j.bmc.2004.04.034