(R)-di-tert-butyl 1-(1-amino-3-ethoxy-1,3-dioxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

Base Information

• Chemical Name: (R)-di-tert-butyl 1-(1-amino-3-ethoxy-1,3-dioxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate
• CAS No.: 1190830-44-4
• Molecular Formula: C₂₁H₃₁N₃O₇
• Molecular Weight: 437.493
• Mol file: 1190830-44-4.mol

Synonyms:(R)-di-tert-butyl 1-(1-amino-3-ethoxy-1,3-dioxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

Chemical Property of (R)-di-tert-butyl 1-(1-amino-3-ethoxy-1,3-dioxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R)-di-tert-butyl 1-(1-amino-3-ethoxy-1,3-dioxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

There total 1 articles about (R)-di-tert-butyl 1-(1-amino-3-ethoxy-1,3-dioxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

di-tert-butyl-diazodicarboxylate (870-50-8) + ethyl 3-amino-3-oxo-2-phenylpropanoate (42798-15-2) → (R)-di-tert-butyl 1-(1-amino-3-ethoxy-1,3-dioxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate (1190830-44-4)

Guidance literature:

With (R)-N-(2-hydroxyphenyl)-2-(2-hydroxybenzoylamino)-3-methylbutylamide; lanthanum(III) nitrate hexahydrate; D-valine t-butyl ester; In ethyl acetate; at 0 ℃; for 48h; enantioselective reaction; Inert atmosphere;

DOI:10.1248/cpb.c16-00974

Reference yield: 98.0%

(R)-di-tert-butyl 1-(1-amino-3-ethoxy-1,3-dioxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate (1190830-44-4) → ethyl 2-carbamoyl-2-hydrazinyl-2-phenylacetate hydrochloride (1190830-58-0)

Guidance literature:

With hydrogenchloride; In toluene; at 0 ℃; for 1h; optical yield given as %ee;

DOI:10.1021/ja9052653

upstream raw materials:

di-tert-butyl-diazodicarboxylate

ethyl 3-amino-3-oxo-2-phenylpropanoate

Downstream raw materials:

ethyl 2-carbamoyl-2-hydrazinyl-2-phenylacetate hydrochloride