ethyl 2-carbamoyl-2-hydrazinyl-2-phenylacetate hydrochloride

Base Information

• Chemical Name: ethyl 2-carbamoyl-2-hydrazinyl-2-phenylacetate hydrochloride
• CAS No.: 1190830-58-0
• Molecular Formula: C₁₁H₁₅N₃O₃*ClH
• Molecular Weight: 273.719
• Mol file: 1190830-58-0.mol

Synonyms:ethyl 2-carbamoyl-2-hydrazinyl-2-phenylacetate hydrochloride

Chemical Property of ethyl 2-carbamoyl-2-hydrazinyl-2-phenylacetate hydrochloride

Chemical Property:

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Technology Process of ethyl 2-carbamoyl-2-hydrazinyl-2-phenylacetate hydrochloride

There total 1 articles about ethyl 2-carbamoyl-2-hydrazinyl-2-phenylacetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-di-tert-butyl 1-(1-amino-3-ethoxy-1,3-dioxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate (1190830-44-4) → ethyl 2-carbamoyl-2-hydrazinyl-2-phenylacetate hydrochloride (1190830-58-0)

Guidance literature:

With hydrogenchloride; In toluene; at 0 ℃; for 1h; optical yield given as %ee;

DOI:10.1021/ja9052653

Reference yield: 99.0%

ethyl 2-carbamoyl-2-hydrazinyl-2-phenylacetate hydrochloride (1190830-58-0) → (R)-ethyl 2-amino-2-carbamoyl-2-phenylacetate (1190830-59-1)

Guidance literature:

With hydrogen; nickel; In ethanol; acetic acid; at 20 ℃; for 3h; optical yield given as %ee;

DOI:10.1021/ja9052653

upstream raw materials:

(R)-di-tert-butyl 1-(1-amino-3-ethoxy-1,3-dioxo-2-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

Downstream raw materials:

(R)-ethyl 2-amino-2-carbamoyl-2-phenylacetate