1,3,5-tris-(2-(3-(t-butoxycarbonyl)propylmalonyl)ethoxy)benzene

Base Information

• Chemical Name: 1,3,5-tris-(2-(3-(t-butoxycarbonyl)propylmalonyl)ethoxy)benzene
• CAS No.: 864383-29-9
• Molecular Formula: C₄₅H₆₆O₂₁
• Molecular Weight: 943.006
• Mol file: 864383-29-9.mol

Synonyms:1,3,5-tris-(2-(3-(t-butoxycarbonyl)propylmalonyl)ethoxy)benzene

Chemical Property of 1,3,5-tris-(2-(3-(t-butoxycarbonyl)propylmalonyl)ethoxy)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,5-tris-(2-(3-(t-butoxycarbonyl)propylmalonyl)ethoxy)benzene

There total 4 articles about 1,3,5-tris-(2-(3-(t-butoxycarbonyl)propylmalonyl)ethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-{[3-(tert-butoxycarbonyl)propoxy]carbonyl}acetic acid (864383-26-6) + 2,2',2''-(benzene-1,3,5-triyltris(oxy))tris(ethan-1-ol) (46929-51-5) → 1,3,5-tris-(2-(3-(t-butoxycarbonyl)propylmalonyl)ethoxy)benzene (864383-29-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 65h;

DOI:10.1039/b504748j

Reference yield:

4-(benzyloxy)butanoic acid t-butyl ester (611212-49-8) → 1,3,5-tris-(2-(3-(t-butoxycarbonyl)propylmalonyl)ethoxy)benzene (864383-29-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / H₂ / Pd/C / toluene

2: 45 percent / DCC / CH₂Cl₂ / 18 h / 20 °C

3: 85 percent / DMAP; DCC / tetrahydrofuran / 65 h / 20 °C

With dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1039/b504748j

Reference yield:

3,5-dihydroxyphenol (108-73-6) → 1,3,5-tris-(2-(3-(t-butoxycarbonyl)propylmalonyl)ethoxy)benzene (864383-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 25 percent / NBu₄⁽¹⁺⁾*Br^(1-) / dimethylformamide / 14 h / 150 °C

2: 85 percent / DMAP; DCC / tetrahydrofuran / 65 h / 20 °C

With dmap; tetrabutylammomium bromide; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1039/b504748j

upstream raw materials:

2-{[3-(tert-butoxycarbonyl)propoxy]carbonyl}acetic acid

2,2',2''-(benzene-1,3,5-triyltris(oxy))tris(ethan-1-ol)

3,5-dihydroxyphenol

tert-butyl 4-hydroxybutyrate

Downstream raw materials:

C₃₃H₄₂O₂₁