Technology Process of (2',3',4',6'-tetra-O-benzyl-β-D-galactopyranosyl)methyl azide
There total 4 articles about (2',3',4',6'-tetra-O-benzyl-β-D-galactopyranosyl)methyl azide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2',3',4',6'-tetra-O-benzyl-β-D-galactopyranosyl)methyl alcohol;
With
diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
N,N-dimethyl-formamide;
at 100 ℃;
for 2h;
With
sodium azide;
In
N,N-dimethyl-formamide;
at 100 ℃;
for 12h;
Further stages.;
DOI:10.1021/jo0202076
- Guidance literature:
-
(2',3',4',6'-tetra-O-benzyl-β-D-galactopyranosyl)methylamine;
With
imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; potassium carbonate;
In
methanol;
at 20 ℃;
for 4h;
With
hydrogenchloride;
In
water;
DOI:10.1021/jo801670k
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: NaBH4 / methanol / 0.17 h / 0 °C
2.1: diphenylphosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 2 h / 100 °C
2.2: 1.10 g / NaN3 / dimethylformamide / 12 h / 100 °C
With
sodium tetrahydroborate; diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo0202076
