1-(3-bromophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone

Base Information

• Chemical Name: 1-(3-bromophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone
• CAS No.: 1256284-94-2
• Molecular Formula: C₂₁H₂₀BrNO
• Molecular Weight: 382.3
• Mol file: 1256284-94-2.mol

Synonyms:1-(3-bromophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone

Chemical Property of 1-(3-bromophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-bromophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone

There total 5 articles about 1-(3-bromophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-(3-bromophenyl)prop-2-en-1-one (791588-72-2) + 1-methyl-2-(pent-4-enyl)-1H-indole (683799-95-3) → 1-(3-bromophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone (1256284-94-2)

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In 1,2-dichloro-ethane; for 3h; Reflux;

DOI:10.1002/asia.201000315

Reference yield:

[2-(3-bromo-phenyl)-2-oxo-ethyl]-triphenyl-phosphonium; bromide → 1-(3-bromophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone (1256284-94-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol; water / 1 h / 20 °C

1.2: 20 °C / pH 7 - 8

2.1: dichloromethane / Reflux; Inert atmosphere

3.1: Hoveyda-Grubbs catalyst second generation / 1,2-dichloro-ethane / 3 h / Reflux

With Hoveyda-Grubbs catalyst second generation; In methanol; dichloromethane; water; 1,2-dichloro-ethane;

DOI:10.1002/asia.201000315

Reference yield:

1-(3-bromophenyl)-2-(triphenylphosphoranylidene)ethanone (61748-02-5) → 1-(3-bromophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone (1256284-94-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / Reflux; Inert atmosphere

2: Hoveyda-Grubbs catalyst second generation / 1,2-dichloro-ethane / 3 h / Reflux

With Hoveyda-Grubbs catalyst second generation; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1002/asia.201000315

upstream raw materials:

1-(3-bromophenyl)prop-2-en-1-one

1-methyl-2-(pent-4-enyl)-1H-indole

1-(3-bromophenyl)-2-(triphenylphosphoranylidene)ethanone

1-(3-Bromophenyl)ethanone