791588-72-2

Usage

Appearance

Yellow solid

Odor

Strong

State

Solid

Uses

a. Synthesis of various organic compounds
b. Building block in the synthesis of more complex molecules

Biological activities

a. Anticancer
b. Anti-inflammatory
c. Antifungal

Potential therapeutic applications

Treatment of various diseases

Research significance

Valuable tool for scientists and researchers in drug discovery and development

Upstream product

• 18523-22-3 2,3'-dibromoacetophenone 
• 50-00-0 formaldehyd 
• 61748-02-5 1-(3-bromophenyl)-2-(triphenylphosphoranylidene)ethanone 
• 58824-55-8 1-(3-bromo-phenyl)-prop-2-en-1-ol 
• 3132-99-8 m-bromobenzoic aldehyde 
• 2142-63-4 1-(3-Bromophenyl)ethanone 

Downstream Products

• 1218988-60-3 (R)-1-(3-(3-bromophenyl)-3-oxopropyl)-2-oxocyclopentanecarbonitrile 
• 1256284-94-2 1-(3-bromophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone 
• 931430-03-4 1-(3-bromophenyl)-4,4,4-trifluorobutan-1-one 
• 1529771-25-2 1-(3-bromophenyl)-4-chloro-4,4-difluorobutan-1-one 
• 1529771-35-4 4-bromo-1-(3-bromophenyl)-4,4-difluorobutan-1-one 
• 137039-82-8 1-(3-bromophenyl)-3-methoxy-1-propanone 
• 1075178-72-1 (S)-1-(3-bromophenyl)prop-2-en-1-ol 
• 1075178-88-9 (R)-(3-bromophenyl)((S)-oxiran-2-yl)methanol 
• 1282033-78-6 (1R,2R)-(3-bromophenyl)-2,3-glycidol 

Relevant academic research and scientific papers

Enantioselective synthesis of 3-substituted 1,2-oxazinanes via organocatalytic intramolecular aza-Michael addition

A highly enantioselective intramolecular 6-exo-trig aza-Michael addition was developed to afford chiral 3-substituted 1,2-oxazinanes in high yields (up to 99% yield) and good enantioselectivities (up to 98/2 er). These reactions were enabled by a quinine-derived primary-tertiary diamine as a catalyst and pentafluoropropionic acid (PFP) as a co-catalyst.

Oxa-Michael addition promoted by the aqueous sodium carbonate

An efficient Michael addition of alcohols to activated alkenes promoted by sodium carbonate with water as reaction medium has been developed. The reaction provides a general, economical and environmentally friendly approach for the synthesis of β-alkoxycarbonyl compounds.

Boron-trihalide-promoted regioselective ring-opening reactions of gem-difluorocyclopropyl ketones

Boron trihalide-promoted ring-opening reactions of gem-difluorocyclopropyl ketones to give the corresponding β-trifluoromethyl ketones and β-halodifluoromethyl ketones were described. It was found that boron trihalides act as both Lewis acids and nucleophiles and the proximal bond prefers to cleave in this transformation.

Highly efficient route to functionalized tetrahydrocarbazoles using a tandem cross-metathesis/intramolecular-hydroarylation sequence

The scope of the novel ruthenium-catalyzed tandem cross-metathesis/ intramolecular-hydroarylation sequence is described. This methodology offers a practical and efficient synthesis of structurally diverse and complex tetrahydrocarbazoles in good to excellent yields (up to 98%). Moreover, preliminary efforts towards the development of an enantioselective version of the current process by sequential catalysis with ruthenium complex and chiral amine are presented, with high yields and enantioselectivities (up to 88% yield and 91% ee).

Enantioselective organocatalytic cyclopropanation via ammonium ylides

Highly functionalized cyclopropanes can be produced with excellent enantioselectivity through an a mine-catalyzed organocatalytic cyclopropanation process (see scheme). Catalytically generated asymmetric ammonium ylides mediate the reaction, and the cyclopropane products can be produced as either enantiomer by using quinine- or quinidine-derived catalysts.