ETHYL 2-[1-(2,6-DIFLUOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE

Base Information

• Chemical Name: ETHYL 2-[1-(2,6-DIFLUOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE
• CAS No.: 129355-67-5
• Molecular Formula: C₁₅H₁₆F₂N₂O₄
• Molecular Weight: 326.3
• Mol file: 129355-67-5.mol

Synonyms:[1-(2,6-Difluoro-benzoyl)-3-oxo-piperazin-2-yl]-acetic acid ethyl ester

Chemical Property of ETHYL 2-[1-(2,6-DIFLUOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE

Chemical Property:

Purity/Quality:

ETHYL-2-[1-(2,6-DIFLUOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE 95.00% ^*data from reagent suppliers

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Technology Process of ETHYL 2-[1-(2,6-DIFLUOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE

There total 2 articles about ETHYL 2-[1-(2,6-DIFLUOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.1%

2,6-difluorobenzoylchloride (18063-02-0) + ethyl 2-(3-oxopiperazin-2-yl)acetate (33422-35-4,686300-89-0) → [1-(2,6-Difluoro-benzoyl)-3-oxo-piperazin-2-yl]-acetic acid ethyl ester (129355-67-5)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; water; for 4h; Ambient temperature;

DOI:10.1002/jps.2600790519

Reference yield:

Diethyl maleate (141-05-9) → [1-(2,6-Difluoro-benzoyl)-3-oxo-piperazin-2-yl]-acetic acid ethyl ester (129355-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 60.8 percent / propan-2-ol / 6 h / 55 °C

2: 83.1 percent / NaHCO₃ / CHCl₃; H₂O / 4 h / Ambient temperature

With sodium hydrogencarbonate; In chloroform; water; isopropyl alcohol;

DOI:10.1002/jps.2600790519

upstream raw materials:

2,6-difluorobenzoylchloride

ethyl 2-(3-oxopiperazin-2-yl)acetate

Diethyl maleate

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