6-(trifluoromethyl)piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

Base Information

Chemical Name:6-(trifluoromethyl)piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester
CAS No.:1269755-68-1
Molecular Formula:C₁₇H₂₀F₃NO₄
Molecular Weight:359.345
Hs Code.:

Synonyms:6-(trifluoromethyl)piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

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Chemical Property of 6-(trifluoromethyl)piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

Chemical Property:

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Technology Process of 6-(trifluoromethyl)piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

There total 2 articles about 6-(trifluoromethyl)piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1221818-26-3
ethyl 6-(trifluoromethyl)piperidine-3-carboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 1269755-68-1
6-(trifluoromethyl)piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

Guidance literature:: With sodium carbonate; In tetrahydrofuran; water; ethyl acetate; at 25 ℃; for 24h;

Reference yield:

: 597532-36-0
ethyl 6-(trifluoromethyl)nicotinate

: 1269755-68-1
6-(trifluoromethyl)piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon; platinum(IV) oxide / acetic acid / 24 h / 25 °C / 10343.2 Torr

2: sodium carbonate / ethyl acetate; water; tetrahydrofuran / 24 h / 25 °C

With hydrogen; sodium carbonate; platinum(IV) oxide; palladium 10% on activated carbon; In tetrahydrofuran; water; acetic acid; ethyl acetate;

Reference yield:

: 1269755-68-1
6-(trifluoromethyl)piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

: 1269755-67-0
1-(benzyloxycarbonyl)-6-( trifluoromethyl)piperidine-3-carboxylic acid

Guidance literature:: 6-(trifluoromethyl)piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 1.5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; ethyl acetate; pH=~ 4;