C₁₆H₁₅ClFN₃O₃

Base Information

Chemical Name:C₁₆H₁₅ClFN₃O₃
CAS No.:1383735-34-9
Molecular Formula:C₁₆H₁₅ClFN₃O₃
Molecular Weight:351.765
Hs Code.:

C<sub>16</sub>H<sub>15</sub>ClFN<sub>3</sub>O<sub>3</sub>

Synonyms:C₁₆H₁₅ClFN₃O₃

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Chemical Property of C₁₆H₁₅ClFN₃O₃

Chemical Property:

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Technology Process of C₁₆H₁₅ClFN₃O₃

There total 10 articles about C₁₆H₁₅ClFN₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1383735-34-9
C₁₆H₁₅ClFN₃O₃

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -10 °C

1.2: 4 h

2.1: hydrogenchloride / water / 4 h / Reflux

3.1: acetic acid; iron / 2 h / Reflux

4.1: triethylamine / dichloromethane / 18 h

4.2: 1 h

5.1: acetic anhydride; potassium acetate; acetic acid; isopentyl nitrite / toluene / 3 h / Reflux

6.1: potassium carbonate; methanol / 1 h / Reflux

7.1: N-ethyl-N,N-diisopropylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 135 °C / 11251.1 Torr

8.1: potassium carbonate / cis-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 130 °C / microwave irradiation

9.1: hydrogenchloride; hydrogen / platinum(IV) oxide hydrate / 1,4-dioxane; ethanol / 18 h / 760.05 Torr

10.1: sodium hydrogencarbonate / dichloromethane; toluene; water / 1 h / 0 °C

With hydrogenchloride; methanol; hydrogen; potassium acetate; acetic anhydride; iron; sodium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; isopentyl nitrite; 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; platinum(IV) oxide hydrate; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 75-44-5
phosgene

: 1383735-64-5
C₁₅H₁₆FN₃O₂

: 1383735-34-9
C₁₆H₁₅ClFN₃O₃

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water; toluene; at 0 ℃; for 1h;

Reference yield:

: 914358-73-9
5-bromo-2-methylpyridin-3-ylamine

: 1383735-34-9
C₁₆H₁₅ClFN₃O₃

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 18 h

1.2: 1 h

2.1: acetic anhydride; potassium acetate; acetic acid; isopentyl nitrite / toluene / 3 h / Reflux

3.1: potassium carbonate; methanol / 1 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 135 °C / 11251.1 Torr

5.1: potassium carbonate / cis-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 130 °C / microwave irradiation

6.1: hydrogenchloride; hydrogen / platinum(IV) oxide hydrate / 1,4-dioxane; ethanol / 18 h / 760.05 Torr

7.1: sodium hydrogencarbonate / dichloromethane; toluene; water / 1 h / 0 °C

With hydrogenchloride; methanol; hydrogen; potassium acetate; acetic anhydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; isopentyl nitrite; 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; platinum(IV) oxide hydrate; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;